LAMA4

  • Official Full Name

    laminin, alpha 4

  • Overview

    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

  • Synonyms

    LAMA4;laminin, alpha 4;laminin subunit alpha-4;LAMA3;laminin alpha 4 chain;LAMA4*-1;DKFZp686D23145

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • CHO
  • Mammalian cells
  • Mammalian Cell
  • Wheat Germ
  • In Vitro Cell Free System
  • HEK293
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
LAMA4-69527H Recombinant Human Laminin α4, His-tagged E.coli Human His
LAMA4-6956H Recombinant Human Laminin α4, GST-Tagged E.coli Human GST
LAMA4-6952H Active Recombinant Human Laminin α4 CHO Human Non
LAMA4-6954M Active Recombinant Mouse Laminin α4, His-tagged Mammalian cells Mouse His 826-1816 a.a.
LAMA4-3605Z Recombinant Zebrafish LAMA4 Mammalian Cell Zebrafish His
LAMA4-6953H Recombinant Human Laminin α4, GST-tagged Wheat Germ Human GST
LAMA4-8932M Recombinant Mouse LAMA4 Protein Mammalian Cell Mouse His
LAMA4-967HCL Recombinant Human LAMA4 cell lysate Human Non
LAMA4-213H Recombinant Human LAMA4 Protein, His-tagged E.coli Human His Ile832~Lys1039
Lama4-214M Recombinant Mouse Lama4 Protein, His-tagged E.coli Mouse His Gln102~Thr234
LAMA4-276HF Recombinant Full Length Human Lamininα4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1 a.a. - 120 a.a.
LAMA4-4980M Recombinant Mouse LAMA4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
LAMA4-4980M-B Recombinant Mouse LAMA4 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    LAMA4 involved in several pathways and played different roles in them. We selected most pathways LAMA4 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer MMP1A,LAMA2,Flt3l,PTGER2,FN1,NFKBIA,ARAF,PRKCA,BCL2L1,CKS2
    Focal adhesion PPP1R12A,THBS4A,PIK3R5,LAMC2,FLT4,LAMA2,VTNB,ACTB,TNK2,PRKCA
    African trypanosomiasis HBB-B1,HBA-A2,TNF,IL6,HBB,APOA1,FASLG,Fasl,ICAM1,PLCB3
    Amoebiasis ITGB2L,IL10,PLCB2,PLCB3,CXCL8,RAB7,COL4A1,LAMA1,RAB5B,PIK3R3
    Small cell lung cancer LAMB1,IKBKG,AKT1,ITGB1,LAMA5,CCND1,PTGS2,MAX,LAMA3,RELA
    PIK-Akt signaling pathway IL3,FGFR2,FGF22,PKN3,PDGFC,ITGB4,LAMA1,LAMB1,PKN2,IL6R
    Toxoplasmosis SOCS1,CASP8,IFNGR2,MAP3K7,HSPA1L,Toxoplasma Gondii Dense Granule Protein 7,LAMB1,H2-AA,HLA-DQA2,TYK2
    ECM-receptor interaction COL5A2,COL4A6,TNXB,COL6A6,LAMB1,TNR,LAMB3,LAMB2,ITGA10,ITGA8

    Protein Function

    LAMA4 has several biochemical functions, for example, extracellular matrix structural constituent,protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMA4 itself. We selected most functions LAMA4 had, and list some proteins which have the same functions with LAMA4. You can find most of the proteins on our site.

    Function Related Protein
    protein binding JAKMIP1,NRG1,IKZF2,MAFG,PAG1,ZFPM1,ADH1A,DOCK2,HEATR5B,TUBA3E
    extracellular matrix structural constituent TFPI2,IMPG2,COL5A2,PXDN,TINAGL1,CD4,IMPG1,COL4A5,COMP,COL8A2
    receptor binding SSTR3,POMC,FYNB,TNFSF15,FGF8B,CDH5,TRDN,PTK2B,HIST2H3C2,LYN

    Interacting Protein

    LAMA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMA4.

    TP53;DAG1;40038273;GAPDH;PTN;APC;SUMO2;EEF1A1;UNC119;FHL1;TUBB2A;RIF1;ATF7IP;COPS6;UBR1;BRD7;RTN4;ZHX1;MED31

    Resources

    Research Area

    Extracellular Matrix Molecules
    Other ECM Glycoproteins

    References

    • Zhao, W; Han, HB; et al. Suppression of lung cancer cell invasion and metastasis by connexin43 involves the secretion of follistatin-like 1 mediated via histone acetylation. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 43:1459-1468(2011).
    • Huang, XH; Ji, GQ; et al. LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 134:705-714(2008).
    • Berfield, AK; Hansen, KM; et al. Rat glomerular mesangial cells require laminin-9 to migrate in response to insulin-like growth factor binding protein-5. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 291:C589-C599(2006).
    • Richards, A; AlImara, L; et al. The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains. EUROPEAN JOURNAL OF BIOCHEMISTRY 238:813-821(1996).

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