LAIR2
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Official Full Name
leukocyte-associated immunoglobulin-like receptor 2 -
Overview
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LAIR2;leukocyte-associated immunoglobulin-like receptor 2;leukocyte associated Ig like receptor 2;CD306;CD306 antigen;LAIR 2;LAIR-2;LAIR2_HUMAN;Leukocyte associated immunoglobulin like receptor 2;MGC71634;OTTHUMP00000068389;OTTHUMP00000068390;leukocyte-associated Ig-like receptor 2;leukocyte-associated Ig-like receptor-2
Recombinant Proteins
- Human
- HEK293
- Mammalian cells
- CHO cells
- HEK293 cells
- E.coli
- Wheat Germ
- Human Cell
- Rabbit
- In Vitro Cell Free System
- His
- His&Avi
- Fc&Avi
- Non
- His&Fc&Avi
Involved Pathway
LAIR2 involved in several pathways and played different roles in them. We selected most pathways LAIR2 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAIR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | AP1G1,RNF41,THEM4,NRG3,UBE2L6,WWP1,CTSL1,CTSK,RNF6,ASB17 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | CD160,LILRA3,LAIR1,KLRB1F,SIGLEC7,AF251705,SIGLEC9,SLAMF6,CLEC2H,CD300A |
| Immune System | SOCS3A,SIGLEC8,AP1S3A,EVL,KLRG1,DCTN3,ASB9,IFIT14,CD300E,CD200R4 |
Protein Function
LAIR2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAIR2 itself. We selected most functions LAIR2 had, and list some proteins which have the same functions with LAIR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | UBXN8,TIPIN,EVL,HIRIP3,CCDC41,CSNK1D,FTL,DIEXF,FAM151B,SPHK1 |
Interacting Protein
LAIR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAIR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAIR2.
SGTA;EMILIN1
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesLAIR Family
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
Monocyte Markers
Related Services
Related Products
References
- Xie, X; Wang, CY; et al. Development and evaluation of a sandwich ELISA method for the detection of human CD306. JOURNAL OF IMMUNOLOGICAL METHODS 396:65-73(2013).
- Meyaard, L; de Vries, ARV; et al. The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR) (Retracted Article. See vol 198, pg 1129, 2003). JOURNAL OF EXPERIMENTAL MEDICINE 194:107-112(2001).
- Meyaard, L; Adema, GJ; et al. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. IMMUNITY 7:283-290(1997).
