KREMEN2
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Official Full Name
kringle containing transmembrane protein 2 -
Overview
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. -
Synonyms
KREMEN2;kringle containing transmembrane protein 2;kremen protein 2;KRM2;MGC10791;Dickkopf receptor 2;KREMEN 2;Kremen protein 2 precursor;Kringle containing protein marking the eye and the nose;Kringle domain containing transmembrane protein 2;KRM 2;MGC16709;kringle domain-containing transmembrane protein 2;kringle-containing protein marking the eye and the nose
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Rat
- Mammalian Cells
- C-His
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Fc
- His&Avi
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
KREMEN2 involved in several pathways and played different roles in them. We selected most pathways KREMEN2 participated on our site, such as Disease,Diseases of signal transduction,Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with KREMEN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Presenilin action in Notch and Wnt signaling | AES,WIF1,TLE1 |
| Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling | KREMEN1 |
| Signaling by WNT in cancer | TNKS,KREMEN1,RNF43,TNKS2 |
| Disease | APOBEC3G,ANTXR2,GPC5,GCKR,NMT2,RLBP1,TNKS2,OGN,OPN1LW,NUP35 |
| Signal Transduction | WLS,TAX1BP1B,UTS2D,OPN4A,GPBAR1,PRC1,OXER1,CNR2,RARG,RDH14 |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | KREMEN1,WIF1 |
| Signaling by Wnt | RSPO2,RSPO1,USP34,WLS,GPR177,TNKS,SOX4B,CSNK1G2,RSPO4,RNF43 |
| Diseases of signal transduction | KREMEN1,CDK8,CTBP2,TTR,HEYL,OPN1MW2,JAG1,RNF43,HEY1,HDAC5 |
Protein Function
KREMEN2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by KREMEN2 itself. We selected most functions KREMEN2 had, and list some proteins which have the same functions with KREMEN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
KREMEN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KREMEN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KREMEN2.
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References
- Qian, LL; Cai, CZ; et al. Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake. SCIENCE CHINA-LIFE SCIENCES 57:469-481(2014).
- Li, XD; Grisanti, M; et al. Dickkopf-1 Regulates Bone Formation in Young Growing Rodents and Upon Traumatic Injury. JOURNAL OF BONE AND MINERAL RESEARCH 26:2610-2621(2011).
- Davidson, G; Mao, BY; et al. Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning. DEVELOPMENT 129:5587-5596(2002).
