KPNA5
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Official Full Name
karyopherin alpha 5 (importin alpha 6) -
Overview
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. -
Synonyms
KPNA5;karyopherin alpha 5 (importin alpha 6);importin subunit alpha-6;IPOA6;SRP6;IMA5_HUMAN;Importin alpha 6;Importin subunit alpha 6;IPOA 6;Karyopherin alpha 5;Karyopherin alpha 5 importin alpha 6;Karyopherin subunit alpha 5;Karyopherin subunit alpha-5;KPNA 5;SRP 6;OTTHUMP00000017076
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&T7
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KPNA5-2661Z | Recombinant Zebrafish KPNA5 | Mammalian Cells | Zebrafish | His |
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| KPNA5-29811TH | Recombinant Human KPNA5 | Wheat Germ | Human | Non | 539 amino acids |
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| KPNA5-3303R | Recombinant Rat KPNA5 Protein | Mammalian Cells | Rat | His |
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| KPNA5-86H | Recombinant Human KPNA5 protein, T7/His-tagged | E.coli | Human | His&T7 |
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| KPNA5-4888HCL | Recombinant Human KPNA5 293 Cell Lysate | HEK293 | Human | Non |
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| Kpna5-1720R | Recombinant Rat Kpna5 Protein, His-tagged | E.coli | Rat | His | Met1-Asp285 |
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| KPNA5-2377H | Recombinant Human KPNA5 Protein, His-tagged | E.coli | Human | His | Met1-Ser351 |
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| KPNA5-274HF | Recombinant Full Length Human KPNA5 Protein | In Vitro Cell Free System | Human | Full L. 539 amino acids |
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| KPNA5-2959R | Recombinant Rat KPNA5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KPNA5-2959R-B | Recombinant Rat KPNA5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KPNA5-4893H | Recombinant Human KPNA5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| KPNA5-5819HF | Recombinant Full Length Human KPNA5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 539 amino acids |
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Involved Pathway
KPNA5 involved in several pathways and played different roles in them. We selected most pathways KPNA5 participated on our site, such as Antiviral mechanism by IFN-stimulated genes,Cytokine Signaling in Immune system,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antiviral mechanism by IFN-stimulated genes | EIF4G1,IFIT11,EIF4G2,NUP35,EIF4G2A,NUPL2,ARIH1L,DPF1,IFIT14,KPNA4 |
| Infectious disease | APOBEC3G,TAF1L,AP1S1,STX1B,KPNA4,PACS1,AP1G1,VPS37A,DOCK2,CCDC167 |
| Immune System | HUWE1,AP1B1,NPEPPS,WWP1,CLEC4A,DHX9,SH2D1B,ASB10,IgG3,WASF2 |
| Influenza Infection | CPSF4,KPNA3,IPO5,KPNA4 |
| Cytokine Signaling in Immune system | SPNA2,DUSP4,DUSP2,MARK3,FRS3,TRIM22,CSF2RB,DUSP9,IFIT11,TRIM3 |
| Host Interactions with Influenza Factors | CPSF4,KPNA3,KPNA4 |
| ISG15 antiviral mechanism | USP18,IFIT10,KPNA4,ARIH1,MX2,ARIH1L,IFIT14,EIF4G2A,KPNA3,IFIT12 |
| Disease | HEY1,HEY2,CTBP2,OS9,SFTPC,FMOD,TNKS,GYG1,PSTPIP2,LRRFIP1 |
Protein Function
KPNA5 has several biochemical functions, for example, nuclear localization sequence binding,protein binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA5 itself. We selected most functions KPNA5 had, and list some proteins which have the same functions with KPNA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nuclear localization sequence binding | IPO13,RANBP6,KPNA3,BRAP,NFKBIA,IPO4,KPNA1,TNPO3,KPNB1,KPNA4 |
| protein binding | BMX,SETD2,ITGA2,FAM212A,RRM2,PACSIN2,RAVER2,PEX11B,SQSTM1,PPP1R15A |
| protein transporter activity | AP1S3B,XPO1,RAMP2,RUFY1,C11orf73,AP4S1,AP4B1,KPNB1,SOSTDC1B,VPS26B |
Interacting Protein
KPNA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA5.
CDKN1B;SPOPL;ANP32B;NUP50;csp_playo;SKP2;ANP32A;SF1;q5nem9_fratt
Resources
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References
- Chaudhary, SC; Cho, MG; et al. A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met. EXPERIMENTAL AND MOLECULAR MEDICINE 46:-(2014).
- Byrum, CA; Smith, J; et al. Restricted expression of karyopherin alpha mRNA in the sea urchin suggests a role in neurogenesis. GENE EXPRESSION PATTERNS 16:51-60(2014).
