KLK4
-
Official Full Name
kallikrein-related peptidase 4 -
Overview
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
KLK4;kallikrein-related peptidase 4;ARM1;EMSP;PSTS;AI2A1;EMSP1;KLK-L1;PRSS17;kallikrein;kallikrein-4;prostase;serine protease 17;kallikrein-like protein 1;androgen-regulated message 1;enamel matrix serine protease 1;enamel matrix serine proteinase 1;ESMP1
Recombinant Proteins
- Human
- Mouse
- Rat
- HEK293
- Human
- Mammalian cells
- E.coli
- Human Cell
- Human Plasma
- Sprague-Dawley Rat Plasma
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&GST
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KLK4-1169H | Active Recombinant Human KLK4 protein, His-tagged | HEK293 | Human | His | Met1-Ser254 | |
| KLK4-1358H |
Active Recombinant Human Kallikrein-Related Peptidase 4
|
Human | Human | Non |
|
|
| KLK4-555H |
Active Recombinant Human KLK4 Protein, His-tagged
|
Mammalian cells | Human | His | Ser27-Ser254 |
|
| KLK4-685H | Recombinant Human KLK4 Protein, His-tagged | E.coli | Human | His | Ser27~Ser254 |
|
| Klk4-686M | Recombinant Mouse Klk4 Protein, His/GST-tagged | E.coli | Mouse | His&GST | Ile32~Asn255 |
|
| Klk4-687R | Recombinant Rat Klk4 Protein, His-tagged | E.coli | Rat | His | Ile32~Arg256 |
|
| KLK4-2044HCL | Recombinant Human KLK4 cell lysate | Human Cell | Human | Non |
|
|
| KLK4-078H | Recombinant Human KLK4 Protein, His-tagged | HEK293 | Human | His | 254 |
|
| KLK4-238H | Native Human Kallikrein | Human Plasma | Human | Non |
|
|
| KLK4-239R | Native Rat Kallikrein | Sprague-Dawley Rat Plasma | Rat | Non |
|
|
| KLK4-3233H | Recombinant Human KLK4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| KLK4-3233H-B | Recombinant Human KLK4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
||
| KLK4-3313H | Recombinant Human KLK4 Protein (Ser27-Ser254), C-His tagged | Mammalian cells | Human | His | Ser27-Ser254 |
|
| KLK4-4936H | Recombinant Human KLK4 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| KLK4-5857HF | Recombinant Full Length Human KLK4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 254 amino acids |
|
Involved Pathway
KLK4 involved in several pathways and played different roles in them. We selected most pathways KLK4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
KLK4 has several biochemical functions, for example, metal ion binding,protein binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK4 itself. We selected most functions KLK4 had, and list some proteins which have the same functions with KLK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | KLK9,GZME,HGF,CELA3B,HTRA1B,CFI,RHBDD1,CMA1,FURINB,KLK1B16 |
| serine-type peptidase activity | KLK1B26,MCPT9,KLK1B22,KLK1B5,CMA1,IRBP,ST14,DPP8,HPN,TMPRSS2 |
| protein binding | SEPT1,CRELD2,CALR,NFIL3,TGM2,RIC8A,TESC,NCAPD2,DNAJC15,CXADR |
| metal ion binding | TKTL1,EYA1,PON3,NAIP7,AMPD3,CYB5A,MARCH11,ZFP14,TTC4,ZBTB1 |
Interacting Protein
KLK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK4.
TYRO3
Resources
Research Area
Serine Proteases and RegulatorsFibrinolysis System
Plasmin/Plasminogen and Kallikrein/Kinin Systems
Related Services
Related Products
References
- Yang, F; Chen, YZ; et al. Stromal TGF-beta signaling induces AR activation in prostate cancer. ONCOTARGET 5:10854-10869(2014).
- Debelec-Butuner, B; Alapinar, C; et al. Inflammation-Mediated Abrogation of Androgen Signaling: An In Vitro Model of Prostate Cell Inflammation. MOLECULAR CARCINOGENESIS 53:85-97(2014).
