Kirrel3
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Official Full Name
kin of IRRE like 3 (Drosophila) -
Overview
The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in this gene are associated with mental retardation autosomal dominant type 4 (MRD4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
KIRREL3;kin of IRRE like 3 (Drosophila);kin of IRRE-like protein 3;KIAA1867;KIRRE;NEPH2;Kin of IRRE like 3;Kin of irregular chiasm like protein 3;MRD4;Nephrin like 2;PRO19814;PRO4502;UNQ5923;nephrin-like 2;OTTHUMP00000231130;OTTHUMP00000231131;OTTHUMP00000231132;nephrin-like protein 2;kin of irregular chiasm-like protein 3
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cells
- GST
- His
- Non
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KIRREL3-389H | Recombinant Human KIRREL3, GST-tagged | E.coli | Human | GST | 28-381aa | |
| Kirrel3-4028M | Active Recombinant Mouse Kirrel3 protein(Met1-Ala535), His-tagged | HEK293 | Mouse | His | Met1-Ala535 | |
| Kirrel3-8741R | Recombinant Rat Kirrel3 protein(Met1-Ala523), His-tagged | HEK293 | Rat | His | 1-523 a.a. |
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| KIRREL3-1238RCL | Recombinant Rat KIRREL3 cell lysate | Human Cells | Rat | Non |
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| KIRREL3-1921MCL | Recombinant Mouse KIRREL3 cell lysate | Human Cells | Mouse | Non |
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| KIRREL3-1010H | Recombinant Human KIRREL3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Kirrel3-3695M | Recombinant Mouse Kirrel3 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| KIRREL3-554H | Recombinant Human KIRREL3 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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Involved Pathway
Kirrel3 involved in several pathways and played different roles in them. We selected most pathways Kirrel3 participated on our site, such as Cell-Cell communication,Nephrin interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kirrel3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nephrin interactions | NPHS1,KIRRELB,KIRREL2,KIRREL,KIRRELA,KIRREL3L |
| Cell-Cell communication | INADL,CLDN4,COL17A1,F11R.2,DSCAMA,NPHS1,DST,CDH3,COL17A1A,CADM2B |
Protein Function
Kirrel3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kirrel3 itself. We selected most functions Kirrel3 had, and list some proteins which have the same functions with Kirrel3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EPB42,RAB8B,LOC780933,GAST,RAD51,EPS15,BLOC1S5,RORB,TFDP1,CEACAM6 |
Interacting Protein
Kirrel3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Kirrel3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Kirrel3.
Resources
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References
- Lee, W; Yun, JM; et al. MeCP2 regulates activity-dependent transcriptional responses in olfactory sensory neurons. HUMAN MOLECULAR GENETICS 23:6366-6374(2014).
- Saatchi, M; Schnabel, RD; et al. Large-effect pleiotropic or closely linked QTL segregate within and across ten US cattle breeds. BMC GENOMICS 15:-(2014).
