KIR2DS2
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Official Full Name
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 -
Overview
KIR2D members of the killer cell immunoglobulin (Ig) like receptor (KIR) family, CD158a (KIR2DL1 and KIR2DS1), CD158b (KIR2DS2) and P50.3 are cell surface glycoproteins with two Ig domains, which are expressed on natural killer cells and some T cells. -
Synonyms
KIR2DL+KIR2DS1+KIR2DS2;killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2;KIR2DS2;killer cell immunoglobulin-like receptor 2DS2;183ActI;CD158J;cl 49;nkat5;NKAT-5;p58 KIR;1060P11.9.2;NK receptor 183 ActI;p58 NK receptor CL-49;MHC class I
Recombinant Proteins
- Human
- E.coli
- HEK293
- Mammalian Cells
- Human Cells
- His&GST
- Non
- His
- Fc
- GST
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
KIR2DS2 involved in several pathways and played different roles in them. We selected most pathways KIR2DS2 participated on our site, such as Adaptive Immune System,Antigen processing and presentation,DAP12 interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | PIK3R2,SHC1,KLRD1,Casp3,NCR3,ITGB2,PIK3CD,FCGR3,IFNA10,IFNA1 |
| Innate Immune System | CD300LB,CASP2,DHX9,CNPY3,GZMM,TLR6,Txn1,SIGIRR,CASP4,PANX1B |
| Antigen processing and presentation | HSPA1L,H2-AA,Ctsl,HLA-C,HLA-B,PDIA3,HSPA4,KIR3DL2,HLA-DRB3,HLA-DRA |
| Adaptive Immune System | LILRA1,SIGLEC6,LILRB4,FBXO44,MKRN1,KIF2B,CTSO,CD300E,KIF5B,MGC174152 |
| Immune System | DEFB125,GBP5,CLEC4D,MAP3K8,KIF5B,GHRB,LAIR1,CRCP,DEFB4B,GBP4 |
| DAP12 interactions | ADRBK1,LCP2A,PRKAR1AA,FRS2A,DUSP2,NEFLB,AGO1,SPTBN2,DAB2IPB,MOV10 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | SIGLEC10,AF251705,CD300E,RAET1E,TREML2,CLEC2B,SIGLEC5,LAIR1,KLRG1,CD300LF |
Protein Function
KIR2DS2 has several biochemical functions, for example, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DS2 itself. We selected most functions KIR2DS2 had, and list some proteins which have the same functions with KIR2DS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | MRC1,LYVE1,Cd79a,TLR2,IL1R1,ERBB2,TLR6,NPR2,NPC1,GHRHRL |
Interacting Protein
KIR2DS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR2DS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR2DS2.
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References
- Ordonez, D; Gomez-Lozano, N; et al. Molecular characterisation of KIR2DS2(star)005, a fusion gene associated with a shortened KIR haplotype. GENES AND IMMUNITY 12:544-551(2011).
- David, G; Morvan, M; et al. Discrimination between the main activating and inhibitory killer cell immunoglobulin-like receptor positive natural killer cell subsets using newly characterized monoclonal antibodies. IMMUNOLOGY 128:172-184(2009).
- Toloza, SMA; Pellett, FJ; et al. Association of killer cell immunoglobulin-like receptor genotypes with vascular arterial events and anticardiolipin antibodies in patients with lupus. LUPUS 17:793-798(2008).
- Lafarge, X; Pitard, V; et al. Expression of MHC class receptors confers functional intraclonal heterogeneity to a reactive expansion of gamma delta T cells. EUROPEAN JOURNAL OF IMMUNOLOGY 35:1896-1905(2005).
