KDM3A
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Official Full Name
lysine (K)-specific demethylase 3A -
Overview
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. -
Synonyms
KDM3A;lysine (K)-specific demethylase 3A;TSGA;JMJD1;JHDM2A;JHMD2A;JMJD1A;KIAA0742;DKFZp686A24246;DKFZp686P07111;lysine-specific demethylase 3A;OTTHUMP00000160707;OTTHUMP00000203309;testis-specific protein A;jumonji domain containing 1;jumonji domain containing 1A;jumonji domain-containing protein 1A;jumonji C domain-containing histone demethylase 2A;jmjC domain-containing histone demethylation protein 2A
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- His
- GST
- Flag
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
KDM3A involved in several pathways and played different roles in them. We selected most pathways KDM3A participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDMs demethylate histones | PHF8,KDM1A,KDM1B,JHDM1D,KDM2B,KDM5B,KDM2AA,KDM5C,ARID5B,KDM4B |
| Chromatin organization | USP22,DMAP1,MCRS1,KDM7AB,KDM1B,DR1,PADI4,PRDM16,SMARCA4,SAP130 |
| Chromatin modifying enzymes | CSRP2BP,SMARCE1,SMARCA4,MSL2,MEAF6,SMARCD1,MSL1A,EHMT2,MSL3,ANO9A |
| Coregulation of Androgen receptor activity | PATZ1,KDM4C,TMF1,PIAS3,SNURF,CMTM2,CMTM2A,KDM1A,CARM1,CTDSP2 |
Protein Function
KDM3A has several biochemical functions, for example, androgen receptor binding,core promoter binding,dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM3A itself. We selected most functions KDM3A had, and list some proteins which have the same functions with KDM3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region sequence-specific DNA binding | HDAC1,ATF3,SOX4,TFAP2A,ARNTL,SOX11,BACH1B,NR5A5,POU5F1,NFE2L2 |
| iron ion binding | BA1,CYP2C39,TPH1,NDOR1,CYP27A1,CYP19A1,CALR,CYP3A5,CYP4A10,HBA1 |
| transcription factor activity, sequence-specific DNA binding | SIM1B,NFYAL,FOXG1,NR2F6,PRDM2,ATF4B1,ZBTB17,SALL1A,ZFP354B,TSC22D2 |
| androgen receptor binding | DDX5,NCOA4,CCNE1,PARK7,FOXH1,WIPI1,SMARCA4,RAN,EP300,BRCA1 |
| dioxygenase activity | OGFOD3,TDO2B,ALOX8,ALKBH7,ASPHD2,KDM5D,BCO2L,ADOA,JMJD5,KDM3B |
| core promoter binding | HNRNPU,MTA1,CALCOCO1,GATA1,EZH2,KLF4,CLOCK,IFI16,HDAC2,HDAC6 |
Interacting Protein
KDM3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM3A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM3A.
TCEAL1;RIPK2;Chmp6;POLR2F;CBX2;Chmp3;Dut
Resources
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References
- Parrish, JK; Sechler, M; et al. The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma. ONCOGENE 34:257-262(2015).
- Guo, XQ; Tian, ZT; et al. Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2 alpha. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47:106-113(2015).
