KCNE2
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Official Full Name
potassium voltage-gated channel, Isk-related family, member 2 -
Overview
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008] -
Synonyms
KCNE2;potassium voltage-gated channel, Isk-related family, member 2;LQT5;LQT6;ATFB4;MIRP1;potassium voltage-gated channel subfamily E member 2;minK-related peptide 1;minK-related peptide-1;potassium channel subunit, MiRP1;potassium channel subunit beta MiRP1;voltage-gated K+ channel subunit MIRP1;minimum potassium ion channel-related peptide 1;cardiac voltage-gated potassium channel accessory subunit 2
Recombinant Proteins
- Human
- Rat
- Mouse
- Guinea pig
- In vitro E. coli expression system
- Mammalian Cell
- HEK293
- HEK293T
- E.coli
- E.coli expression system
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
KCNE2 involved in several pathways and played different roles in them. We selected most pathways KCNE2 participated on our site, such as Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric acid secretion | PLCB3,CALM4,CAMK2B,ATP1A1,KCNJ1,CAMK2A,ACTB,CALML3,GNAI2,PRKCG |
Protein Function
KCNE2 has several biochemical functions, for example, contributes_to delayed rectifier potassium channel activity,contributes_to inward rectifier potassium channel activity,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNE2 itself. We selected most functions KCNE2 had, and list some proteins which have the same functions with KCNE2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization | KCNQ1,KCNH2 |
| protein homodimerization activity | CCBL2,DGCR8,HSD17B4,CD8A,ZBTB1,MAP3K12,ALDH1A3,TGFB1,BOKB,HNF1B |
| contributes_to inward rectifier potassium channel activity | KCNJ5,KCNJ3 |
| protein binding | FAM127B,ADAMTS10,SYMPK,SNRNP27,MPP7,CDX4,DOCK9,TPT1,NUP155,PRPS1 |
| contributes_to delayed rectifier potassium channel activity | KCNE1,KCNQ1 |
| ion channel binding | FKBP1B,FYN,AKAP6,KCNB1,ID2,FGF12,SLC14A2,KCNQ1,PRNP,PDE4D |
| potassium channel regulator activity | DRD2,SGK2B,CHP,KCNAB1,DRD4,AMIGO1,PIAS3,YWHAE,SGK2,KCNMB3 |
Interacting Protein
KCNE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNE2.
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References
- Kinoshita, K; Yamaguchi, Y; et al. A Novel Missense Mutation Causing a G487R Substitution in the S2-S3 Loop of Human ether-a-go-go-Related Gene Channel. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 23:1246-1253(2012).
- Zhang, M; Wang, YH; et al. KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 302:H910-H922(2012).
