KCNC1
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Official Full Name
potassium voltage gated channel, Shaw-related subfamily, member 1 -
Overview
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand- gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltagegated ion channels which open and close in response to membrane potential. These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward- rectifier potassium channels, calcium-activated potassium channels, two-poredomain potassium channels, light-gated channels, mechano-sensitive ion channels, and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels and transient receptor potential channels. Potassium voltage-gated channel, Shaw-related subfamily, member 1, also known as KCNC1 or Kv3.1, is a human gene. The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based in sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Kv3.1b has been extensively tested in the auditory regions of mammals, and the decline of Kv3.1b expression appears to correlate with the functional decline in the medial olivocochlear efferent system. Other research shows potential for Kv3.1b channels to be oxygen sensors. -
Synonyms
KCNC1;potassium voltage gated channel, Shaw-related subfamily, member 1;potassium voltage-gated channel subfamily C member 1;voltage-gated potassium channel subunit Kv4;voltage-gated potassium channel subunit Kv3.1;KV4;NGK2;Shaw;Kv3.1;Kcr2-1;KSh
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- His&Fc&Avi
Involved Pathway
KCNC1 involved in several pathways and played different roles in them. We selected most pathways KCNC1 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Voltage gated Potassium channels | KCNC2,KCNB2,KCND1,KCNA1,KCNH2A,KCNC3A,KCNF1A,KCNA5,KCNH5A,KCNAB2B |
| Neuronal System | AKAP5,CHRNB4,KCNA10,SLC1A2A,KCNK16,KCNK6,GJC1,CHRNA5,ARL6IP5A,GLS2B |
| Potassium Channels | KCNJ1A.6,KCNH2A,KCNJ1A.4,KCNC2,KCNJ1,KCNC1B,KCNN1B,KCNK3A,KCNC3A,KCNJ1A.2 |
Protein Function
KCNC1 has several biochemical functions, for example, delayed rectifier potassium channel activity,ion channel binding,kinesin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNC1 itself. We selected most functions KCNC1 had, and list some proteins which have the same functions with KCNC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinesin binding | KIF18B,IFT88,PLEKHM2,AP1G1,KIAA1279,SPAG9A,ARPC2,SYBU,DISC1,ARHGEF10 |
| delayed rectifier potassium channel activity | KCNS3A,KCNG2,KCNC3B,KCNA10,KCNV2B,KCNC1B,KCNG1,KCND1,KCNA5,KCNS3 |
| ion channel binding | KCND3,EPN1,YWHAH,FAM115C,PDE4D,ACTN3,CHERP,FGF13,ACTN4,KCNE2 |
| voltage-gated potassium channel activity | KCNF1A,HCN2,KCNA1,KCNS3A,KCNH2,KCNA2B,KCNMA1,KCNC1A,KCNC2,KCNC1B |
Interacting Protein
KCNC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNC1.
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