ITSN1
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Official Full Name
intersectin 1 (SH3 domain protein) -
Overview
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. -
Synonyms
ITSN1;intersectin 1 (SH3 domain protein);ITSN, SH3D1A;intersectin-1;human intersectin SH3 domain containing protein SH3P17;intersectin 1 short form variant 3;intersectin 1 short form variant;11;intersectin short variant 12;MGC134948;MGC134949;S
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- GST
- His&T7
- Flag
- N-6×His-ABP
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ITSN1-11829Z | Recombinant Zebrafish ITSN1 | Mammalian Cells | Zebrafish | His |
|
|
| ITSN1-16H | Recombinant Human ITSN1, GST-tagged | Wheat Germ | Human | GST | 588-675 a.a. |
|
| ITSN1-28347TH | Recombinant Human ITSN1, His-tagged | E.coli | Human | His | 876-1232 a.a. |
|
| Itsn1-7873R | Recombinant Rat Itsn1 protein, His & T7-tagged | E.coli | Rat | His&T7 | Met1~Gln227 |
|
| ITSN1-8395M | Recombinant Mouse ITSN1 Protein | Mammalian Cells | Mouse | His |
|
|
| ITSN1-09H | Recombinant Human ITSN1 Over-expression Lysate, C-Flag tagged | HEK293 | Human | Flag | Full Length |
|
| ITSN1-11H | Recombinant Human ITSN1 protein, His-tagged | E.coli | Human | His | Gln341-Gln530 |
|
| ITSN1-13H | Recombinant Human ITSN1 Protein, N-6×His-ABP tagged | E.coli | Human | N-6×His-ABP |
|
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| Itsn1-1702M | Recombinant Mouse Itsn1 Protein, His-tagged | E.coli | Mouse | His | Met1-Pro151 |
|
| ITSN1-4660M | Recombinant Mouse ITSN1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| ITSN1-4660M-B | Recombinant Mouse ITSN1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
ITSN1 involved in several pathways and played different roles in them. We selected most pathways ITSN1 participated on our site, such as Axon guidance,Cell death signalling via NRAGE, NRIF and NADE,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITSN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell death signalling via NRAGE, NRIF and NADE | FGD4,ITGB3BP,BCL2L11,ARHGAP4A,TRIO,ARHGEF16,TIAM2,PLEKHG2,AATF,ABR |
| EPHB-mediated forward signaling | ACTR2B,EPHB4B,ARPC3,EFNB2A,EFNB3,EFNB3B,ARPC2,ACTR3,ARPC5,ACTR2 |
| EPH-Ephrin signaling | AP2A2,ARHGEF28,EPHA4A,EFNB2A,EFNA1,EFNB1,SHB,EFNA1B,MYL9,CLTB |
| EPHB forward signaling | EFNB2,EFNB3,GRB7,EFNA5,EFNB1 |
| Developmental Biology | SCN2B,LIN28A,BOC,RHOGA,NADL1.1,PLXNC1,PAK4,CDK19,CSNK2A2,RASGRP1 |
| Axon guidance | CDK5R1B,KIF4,KBTBD7,TRPC4,NTNG1,SEMA5A,ABLIM3,SEMA6A,GSK3B,DCC |
| G alpha (12/13) signalling events | ARHGEF3,ARHGAP4A,FGD4,RHOAE,ADRA1D,RHOB,AKAP13,DCLRE1B,ARHGEF1B,ABR |
| GPCR downstream signaling | ANXA1B,TRPC3,ADORA1,CCR3,ADRA2B,ARHGEF18,GPR65,SSTR3,HEBP1,CCL19A.2 |
Protein Function
ITSN1 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,calcium ion binding,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITSN1 itself. We selected most functions ITSN1 had, and list some proteins which have the same functions with ITSN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF434,RG9MTD1,FZD10,NFKBID,TNKS,ABCG2,SCAND1,TRAF4,RIN1,DRD2 |
| Rho guanyl-nucleotide exchange factor activity | ITSN2A,BCR,ARHGEF7B,DNMBP,RASGRF2B,ARHGEF1A,TRIOA,FGD3,DOCK10,PLEKHG5 |
| protein complex scaffold | CAV3,MAGI3,AKAP9,AXIN1,ARRB2,MPP7,KLHL17,ISCU,DLG1,HOMER1 |
| kinase activator activity | TAB1,MOBKL1A |
| calcium ion binding | SLIT1A,NOTCH2,RAB11FIP4,SYT10,PCDH1G31,MYLPF,RCN3,TESC,S100A5,BMP1 |
| proline-rich region binding | CCND1,CYLD,BAIAP2,PRPF40A,PFN1,ABL1,NEDD4,TCERG1,GHR,ABI2 |
| guanyl-nucleotide exchange factor activity | DOCK5,RASGRF2B,RAPGEF6,ARHGEF39,DOCK7,ARHGEF3L,KALRN,P2RY12,FFAR1,ARHGEF19 |
Interacting Protein
ITSN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITSN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITSN1.
CBL;DNM2;WASL
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References
- Russo, A; Okur, MN; et al. Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2 beta) isoform contributes to neuroblastoma tumorigenesis. CANCER LETTERS 359:262-268(2015).
- Kong, XD; Liu, N; et al. Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 47:834-841(2014).
