ITM2B
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Official Full Name
integral membrane protein 2B -
Overview
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. -
Synonyms
ITM2B;integral membrane protein 2B;BRI;E3 16;E25B;ABRI;ABri/ADan amyloid peptide;BRI 2;BRI2;BRICD 2B;BRICD2B;BRICHOS domain containing 2B;FBD;ITM 2B;ITM2B_HUMAN;Protein E25B;Transmembrane protein BRI;OTTHUMP00000018394;OTTHUMP00000018395;E3-16
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Chicken
- Mouse
- Mus musculus
- Pan troglodytes
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
ITM2B involved in several pathways and played different roles in them. We selected most pathways ITM2B participated on our site, such as Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITM2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diurnally regulated genes with circadian orthologs | QKI,SF3A3,G0S2,CRY1,GFRA1,UCP3,PURA,STBD1,NR1D2,DAZAP2 |
Protein Function
ITM2B has several biochemical functions, for example, SH3 domain binding,mRNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITM2B itself. We selected most functions ITM2B had, and list some proteins which have the same functions with ITM2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | UTP11L,DHX8,DKC1,RPL17,RPL10,RPL15,CORO1A,RPS15,MTIF2,ESF1 |
| protein binding | TEK,ARL4D,FBXW5,GP1BA,SH3GL2,TTC30B,COPS4,LACTB2,MEOX2,CSRNP2 |
| SH3 domain binding | DENND1A,ZFP106,LYN,LRP2,SKAP1,USP8,VASP,INPPL1B,PDE4D,DOCK4 |
| mRNA binding | NUDT21,SNRPC,LIN28A,RC3H2,SLBP,QK,RBM38,TSN,IGF2BP2A,NXF3 |
Interacting Protein
ITM2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITM2B here. Most of them are supplied by our site. Hope this information will be useful for your research of ITM2B.
NAALADL2;SYNE4;CCDC155;env;CREB3;UL25;q7ard3_yerpe;fldB;q8d0s2_yerpe;eno;Nek2;Shoc2
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References
- Wu, WH; Fang, Y; et al. The 2b protein as a minor structural component of PRRSV. VIRUS RESEARCH 114:177-181(2005).
- Fricke, B; Argent, AC; et al. The "stomatin" gene and protein in overhydrated hereditary stomatocytosis. BLOOD 102:2268-2277(2003).
