ITGAX
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Official Full Name
integrin, alpha X (complement component 3 receptor 4 subunit) -
Overview
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ITGAX;integrin, alpha X (complement component 3 receptor 4 subunit);CD11C;SLEB6
Recombinant Proteins
- Human
- Mouse
- HEK293
- E.coli
- Mammalian Cell
- HEK293F
- Insect Cell
- Mammalian cells
- Wheat Germ
- C-Flag&His
- His
- His&GST
- His&Myc
- His&Fc&Avi
- GST
Involved Pathway
ITGAX involved in several pathways and played different roles in them. We selected most pathways ITGAX participated on our site, such as Regulation of actin cytoskeleton,Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tuberculosis | LAMP1,AKT1,IFNA6,IFNA16,ITGB2L,AKT2,CAMK2A,TLR1,HLA-DQA2,CAMP |
| Regulation of Actin Cytoskeleton | FGF4,RAC1B,FGFR1,ARPC4L,FGF9,FGF12A,PIP5K1A,MAPK6,CHRM5B,SCINLA |
Protein Function
ITGAX has several biochemical functions, for example, metal ion binding,protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAX itself. We selected most functions ITGAX had, and list some proteins which have the same functions with ITGAX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | FPR1,TNFRSF11A,ITGB1B.2,MED14,NRXN1,TREML2,SMAGP,ANPEP,LYVE1,PROCR |
| protein binding | NSF,NUP62CL,CHORDC1,ITGA3,CHEK1,IGF2BP2,TRIM32,PPP3R2,SV2B,MED11 |
| metal ion binding | SMAD9,DNAJA2,ADPRHL2,TRIM8A,CISD3,HMOX2,RORAA,ZNF395,DOM3Z,CA |
Interacting Protein
ITGAX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAX here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAX.
ITGB2;pepT
Resources
Research Area
Natural Killer Cells (NK Cells) MarkersGranulocyte Markers
Integrins
Conventional/Classical Dendritic Cells
Inflammatory/Monocyte-derived Dendritic Cells
Langerhans and Dermal Dendritic Cells
Plasmacytoid Dendritic Cells
Basophils
B Cell Chemotaxis, Migration, and Adhesion
T Cell Migration
CD Antigen (Granulocyte Markers)
Macrophage Markers
Monocyte Markers
MDSC Phenotyping - Negative Markers
Related Services
Related Products
References
- Immig, K; Gericke, M; et al. CD11c-Positive Cells from Brain, Spleen, Lung, and Liver Exhibit Site-Specific Immune Phenotypes and Plastically Adapt to New Environments. GLIA 63:611-625(2015).
- Williams, KA; Lee, M; et al. A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes. PLOS GENETICS 10:-(2014).
