ITGAV

  • Official Full Name

    integrin, alpha V

  • Overview

    Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.

  • Synonyms

    ITGAV;integrin, alpha V;antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR;integrin alpha-V;CD51;integrin alphaVbeta3;vitronectin receptor s

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • Chicken
  • Rat
  • Bovine
  • E.coli
  • CHO
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Baculovirus-Insect cells
  • Yeast
  • In Vitro Cell Free System
  • Mammalian cells
  • His
  • Non
  • His&T7
  • His&Fc&Avi
  • GST
  • C-His and C-Strep
Cat.# Product name Source (Host) Species Tag Protein Length Price
ITGAV-2775H Recombinant Human ITGAV protein, His-tagged E.coli Human His 819-915 aa
ITGAVB3-103H Active Recombinant Human ITGAVB3 CHO Human Non 31-992;27-718 a.a.
ITGA5-101H Recombinant Human ITGAV/ITGB3 Heterodimer Protein, His-tagged HEK293 Human His ITGAV(Phe 31 - Val 992)/ITGB3 (Gly 27 - Asp 718)
ITGAV-2315R Recombinant Rhesus monkey ITGAV Protein, His-tagged Mammalian Cell Rhesus macaque His
ITGAV-26862TH Recombinant Human ITGAV protein Wheat Germ Human Non
ITGAV-3406Z Recombinant Zebrafish ITGAV Mammalian Cell Zebrafish His
ITGAV-6763H Recombinant Human ITGAV protein, His-tagged E.coli Human His Pro560~Trp744
Itgav-6764M Recombinant Mouse Itgav protein, His & T7-tagged E.coli Mouse His&T7 Pro71~Asp322
ITGAV-6989C Recombinant Chicken ITGAV Mammalian Cell Chicken His
ITGAV-8360M Recombinant Mouse ITGAV Protein Mammalian Cell Mouse His
ITGAV-877HCL Recombinant Human ITGAV cell lysate Human Non
Itgav&Itgb6-23R Recombinant Rat Itgav&Itgb6 Protein CHO Rat Non
ITGAV-0032B Recombinant Bovine ITGAV Protein (Ala30-Pro993), C-His-tagged Baculovirus-Insect cells Bovine His Ala30-Pro993
ITGAV-1427H Recombinant Human ITGAV Protein (891-1048 aa), His-tagged Yeast Human His 891-1048 aa
Itgav-1700R Recombinant Rat Itgav Protein, His-tagged E.coli Rat His Pro469-Leu918
ITGAV-2136R Recombinant Rhesus Macaque ITGAV Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
ITGAV-2136R-B Recombinant Rhesus Macaque ITGAV Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ITGAV-2343H Recombinant Human ITGAV Protein, His-tagged E.coli Human His Phe31-Gly560
ITGAV-265HF Recombinant Full Length Human ITGAV Protein In Vitro Cell Free System Human Full L.
ITGAV-26H Active Recombinant Human ITGAV Protein, C-6×His-tagged CHO Human His Integrin alpha V: Phe31-Val992<br />Integrin beta 1: Gln21-Asp728
ITGAV-301294H Recombinant Human ITGAV protein, GST-tagged E.coli Human GST Ser819-Gln915
ITGAV-4323H Recombinant Human ITGAV Protein (Met1-Val992), C-His tagged Mammalian cells Human His Met1-Val992
ITGAV-4641M Recombinant Mouse ITGAV Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ITGAV-4641M-B Recombinant Mouse ITGAV Protein Pre-coupled Magnetic Beads HEK293 Mouse
ITGAV-4988H Recombinant Human ITGAV Protein, GST-tagged Wheat Germ Human GST
ITGAV-5749HF Recombinant Full Length Human ITGAV Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1048 amino acids
ITGAV-5819B Recombinant Bovine ITGAV and ITGB6 Protein (Phe31-Pro993, Gly22-Pro709), C-His & C-Strep tagged Mammalian cells Bovine C-His and C-Strep Phe31-Pro993, Gly22-Pro709
ITGAV-6962HF Recombinant Full Length Human ITGAV Protein In Vitro Cell Free System Human Full L. 1048 amino acids

    Involved Pathway

    ITGAV involved in several pathways and played different roles in them. We selected most pathways ITGAV participated on our site, such as Phagosome,PIK-Akt signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAV were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway NOS3,PPP2R3A,PCK1,PGF,COL6A4,IL2RG,GNB2,FGFR1,GNG10,LAMA2
    Focal adhesion FLT1,ITGB7,SHC2,ITGB3B,LAMB1A,MYLPFA,VEGFC,COL5A2A,COL6A5,COL5A1
    Phagosome DYNC2H1,TUBA2,CD209,TUBB,RAB7,CORO1A,TUBB5,ATP6V1C2,C3,TUBA7L
    Cell adhesion molecules (CAMs) CLDNK,JAM2,F11R,ESAM,SPN,CLDN19,CADM1,HLA-DRA,ITGB1B.2,CLDN10
    Hypertrophic cardiomyopathy (HCM) CACNB3,CACNG4,ITGA9,CACNG3,CACNB1,TPM3,SLC8A1,CACNG1,ATP2A2,TNF
    Thyroid hormone signaling pathway PLCE1,MAP2K2,KAT2A,DIO1,MED4,SLC9A1,RXRG,MED14,ACTG1,PRKCB
    ECM-receptor interaction GP1BA,COL6A1,ITGA3B,CD44,TNN,GP6,ITGA1,COL4A6,LAMB2,ITGB4
    Regulation of Actin Cytoskeleton PIP5K1C,GNA13A,ITGA7,FGFR3,FGF6B,TMSB,FGD,PAK2A,INS,GIT1
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGA3,ITGA2,CACNB3,LEF1,ITGA7,LMNA,ACTN3,CDH2,SGCA,ACTB

    Protein Function

    ITGAV has several biochemical functions, for example, extracellular matrix binding,extracellular matrix protein binding,fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAV itself. We selected most functions ITGAV had, and list some proteins which have the same functions with ITGAV. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding ZNF443,FAHD2A,AKAP13,ZNF878,CPEB1,FBXO40.1,ATP8B3,RARAA,ZBED6,NUBPL
    transforming growth factor beta binding TGFBR2,ENG,ACVRL1,TGFB3,VASN,LTBP4,HYAL2,THBS1,LTBP1,TGFBR3
    fibronectin binding LPA,HSD17B12,IGFBP5,MYOC,SFRP2,ITGA3,FSTL3,PLEKHA2,LACRT,LRRC15
    protease binding CCBE1,VWF,INSL3,MALT1,SERPINE1,BCL2,POLG,TIMP3,THAP5,SERPINA1D
    virus receptor activity SLC20A2,PVRL2,CLEC5A,ITGB7,CD209,DPP4,CLDN1,PVR,SCARB2,EFNB3
    extracellular matrix binding SPARC,DCN,TGFBI,ITGA2B,GPR56,SID4,FBLN2,CYR61,CD248,DMP1
    protein binding FOXK2,CLCN1,ZNF329,AGPAT1,FOXP2,STAT6,VPS54,PPFIA1,Rhox5,PPEF1
    extracellular matrix protein binding ITGB8,MEPE
    voltage-gated calcium channel activity CACNA1C,PKD2,CACNB2A,CACNA1DA,CATSPER3,CACNB1,NALCN,CACNA2D2,CACNA1D,TPC3

    Interacting Protein

    ITGAV has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAV here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAV.

    ITGB3;FN1;ITGB5;PPAP2B;VTN;VWF;PTPRZ1

    Resources

    Research Area

    Osteoclast Markers
    Integrins
    Mesenchymal Stem Cell Markers
    Adherens Junction Proteins in Endothelial Cells
    Adherens Junction Proteins in VSMC
    Focal Adhesion Proteins in VSMC
    Osteoblast and Osteoclast Markers
    Mesodermal Lineage Markers
    Integrins in Focal Adhesions
    Basolateral Molecules

    References

    • Shakiba, E; Tavilani, H; et al. The ITGAV-rs3911238 Polymorphism Is Associated with Disease Activity in Rheumatoid Arthritis. IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY 13:356-363(2014).
    • Inamine, T; Nakamura, M; et al. A polymorphism in the integrin alpha V subunit gene affects the progression of primary biliary cirrhosis in Japanese patients. JOURNAL OF GASTROENTEROLOGY 46:676-686(2011).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All ITGAV Products

    Required fields are marked with *

    My Review for All ITGAV Products

    Required fields are marked with *