ITGA7

  • Official Full Name

    integrin, alpha 7

  • Overview

    The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

  • Synonyms

    [a]7;alpha7;ITGA7;integrin, alpha 7;integrin alpha-7
Cat.# Product name Source (Host) Species Tag Protein Length Price
ITGA7-28842TH Recombinant Human ITGA7 Wheat Germ Human Non 100 amino acids
ITGA7-3112R Recombinant Rat ITGA7 Protein Mammalian Cell Rat His
ITGA7-2768R Recombinant Rat ITGA7 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ITGA7-2768R-B Recombinant Rat ITGA7 Protein Pre-coupled Magnetic Beads HEK293 Rat
ITGA7-4994H Recombinant Human ITGA7 Protein, GST-tagged Wheat Germ Human GST
ITGA7-4995H Recombinant Human ITGA7 Protein, His-tagged E.coli Human His Arg648~Ser952

    Involved Pathway

    ITGA7 involved in several pathways and played different roles in them. We selected most pathways ITGA7 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway IL6R,LPAR3,PRKCA,PIK3CD,KITLG,TNR,MLST8,FGF20,THBS2,SGK3
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) GJA1,SGCA,CTNNA1,ACTN1,CACNA2D1,ITGAV,CACNB3,LMNA,ITGA3,ITGA2
    Regulation of Actin Cytoskeleton IQGAP2,PPP1CC,ITGB5,FGF6A,PAK6B,FGF5,FGF8,VIL1,CDC42L2,PAK1
    Dilated cardiomyopathy ITGA3,CACNG8,TPM2,ITGA10,ITGB3,LMNA,ITGA8,PRKACB,SGCB,CACNG6
    ECM-receptor interaction COL11A1A,DAG1,COL5A2A,ITGB7,HSPG2,COL4A1,COL4A4,SDC4,ITGA4,GP9
    Focal adhesion VTNB,VEGFAB,COL5A2A,PRKCBA,ITGB1,VAV3,FYNB,PIK3R3,MAPK10,TLN1
    Hypertrophic cardiomyopathy (HCM) DES,CACNA2D4,PRKAB2,ITGB1,CACNG3,CACNB1,ITGA10,SGCD,LAMA2,CACNG4

    Protein Function

    ITGA7 has several biochemical functions, for example, laminin binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA7 itself. We selected most functions ITGA7 had, and list some proteins which have the same functions with ITGA7. You can find most of the proteins on our site.

    Function Related Protein
    laminin binding NCL,NID1,PLEKHA2,ITGA3,ACHE,LYPD5,LYPD3,ITGA9,LGALS3,CTSS
    metal ion binding GNAI1,GIT2B,PHF20B,STK32B,ZBTB3,DUS3L,KAT8,ACVR2B,NAIP7,HIC2
    protein binding EMP3,CTDNEP1,FREM2,RWDD1,NFKBID,FAM19A1,IVL,KRT18,NHP2,MYO7B

    Interacting Protein

    ITGA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA7.

    FHL2

    Resources

    Research Area

    Muscle Stem Cell Markers
    Myogenesis Markers
    Integrins
    Focal Adhesion Proteins in VSMC
    Myogenic Precursor Markers
    Skeletal Muscle Markers
    Integrins in Focal Adhesions

    References

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    Q&As

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