ISCA1
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Official Full Name
iron-sulfur cluster assembly 1 homolog (S. cerevisiae) -
Overview
ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in;electron-transfer reactions (Cozar-Castellano et al., 2004 (PubMed 15262227)). -
Synonyms
ISCA1;iron-sulfur cluster assembly 1 homolog (S. cerevisiae);HBLD2, HESB like domain containing 2;iron-sulfur cluster assembly 1 homolog, mitochondrial;hIscA;ISA1;MGC4276;GK004;HESB-like domain-containing protein 2;Iron sulfur assembly protein IscA;OTTHUMP00000021590;OTTHUMP00000021592;HESB like domain containing 2;iron-sulfur assembly protein IscA;HBLD2;RP11-507D14.2
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ISCA1 involved in several pathways and played different roles in them. We selected most pathways ISCA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ISCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ISCA1 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding,4 iron, 4 sulfur cluster binding,ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ISCA1 itself. We selected most functions ISCA1 had, and list some proteins which have the same functions with ISCA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | KRT18,SEPT7,EPB41L1,KRT4,CLTA,KRT77,TUBA1C,CLDN15B,CLDN17,KRT222 |
| 2 iron, 2 sulfur cluster binding | AIFM4,ISCA2,AIFM3,CISD3,NDUFV2,CMAH,CISD2,CIAPIN1,AOX1,RFESD |
| ferrous iron binding | Trf,NT5E,FTO,ACP5,ISCUB,ALKBH1,UROD,ISCU,FECH,SERPINB1A |
| 4 iron, 4 sulfur cluster binding | RSAD1,MUTYH,ERCC2,IREB2,NDUFS8A,NUBPL,POLA1,NDUFS8,NDUFS2,NFU1 |
Interacting Protein
ISCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ISCA1.
q9r8c5_yerpe;ICT1;ENTHD2
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References
- Al-Hassnan, ZN; Al-Dosary, M; et al. ISCA2 mutation causes infantile neurodegenerative mitochondrial disorder. JOURNAL OF MEDICAL GENETICS 52:186-194(2015).
- Brancaccio, D; Gallo, A; et al. Formation of [4Fe-4S] Clusters in the Mitochondrial Iron-Sulfur Cluster Assembly Machinery. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136:16240-16250(2014).
