IRS1
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Official Full Name
insulin receptor substrate 1 -
Overview
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] -
Synonyms
IRS1;insulin receptor substrate 1;HIRS-1;IRS-1
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- HEK293T
- Sf9 Insect Cell
- E.coli
- Mammalian Cell
- HEK293
- Mamanlian cells
- Myc&DDK
- GST
- Non
- His
- His&T7
- His&Fc&Avi
- N-MBP&C-His-Avi
- Flag
Involved Pathway
IRS1 involved in several pathways and played different roles in them. We selected most pathways IRS1 participated on our site, such as cGMP-PKG signaling pathway,FoxO signaling pathway,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | PTEN,LPAR4,VEGFC,LAMB1,LAMB2,IBSP,PIK3R5,TP53,FGF12,LPAR2 |
| cGMP-PKG signaling pathway | SLC25A6,CALM2,PLCB1,AKT2,ATP2A1,GNAI3,ATP1B2,MEF2C,ITPR3,SLC25A31 |
| MicroRNAs in cancer | PTEN,TRIM71,MAP2K2,CCNE1,HOXD10,BCL2,EZR,NOTCH3,PDCD4,CCND2 |
| Insulin resistance | G6PC3,IRS2,PRKAB2,PRKCB,PYGM,PPARA,MGEA5,OGT.1,ACACB,GSK3B |
| mTOR signaling pathway | PRKAA1,PRKCG,AKT1S1,RPS6KA6,RPS6KA3,PIK3CA,VEGFAA,IKBKB,VEGFA,EIF4E2RS1 |
| Aldosterone-regulated sodium reabsorption | SCNN1B,ATP1A1,IGF1,NR3C2,SCNN1G,PIK3CA,SLC9A3R2,PRKCA,MAPK3,ATP1A3 |
| FoxO signaling pathway | KLF2B,RBL2,AKT1,MAPK11,NLK1,STK4,INSRB,GRB2B,RAF1,TGFBR1 |
| Non-alcoholic fatty liver disease (NAFLD) | DDIT3,NDUFA12,COX7A2L,PPARA,NDUFA1,IKBKB,SOCS3,NDUFA13,NDUFB1,UQCRQ |
| Type II diabetes mellitus | IRS4,PRKCZ,INS1,IRS2,HK1,INS2,INS-IGF2,PIK3R1,SOCS4,PIK3CA |
Protein Function
IRS1 has several biochemical functions, for example, SH2 domain binding,insulin receptor binding,insulin-like growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS1 itself. We selected most functions IRS1 had, and list some proteins which have the same functions with IRS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane receptor protein tyrosine kinase adaptor activity | PIK3R1,GAB2,FRS2,BLNK,TRAT1,DOK2,SHC1,STAP1,SH2B2 |
| protein kinase C binding | ADAM9,GRK5,PICK1,HINT1,PEA15A,DACT2,PRKCSH,HDAC7A,FLNA,SDC4 |
| signal transducer activity | TAAR13D,TRHRB,PLCB4,GNG13B,HCAR1-2,GPR186,VIPR1B,MRGPRH,OLFR1440,OLFR150 |
| SH2 domain binding | LCK,CRK,NLK,DLC1,SIT1,ARHGAP5,INPPL1,GNB2L1,DAG1,SQSTM1 |
| insulin receptor binding | FRS3,INS1,PHIP,DOK1B,PIK3R1,DOK6,SNX4,FRS2,IRS4,PTPN1 |
| phosphatidylinositol 3-kinase binding | IGF1RB,LCK,INSRA,DAB1,INSR,FLT3,INSRR,PIK3R1,HCST,CALM1 |
| insulin-like growth factor receptor binding | YWHAH,YWHAG,IGF2A,REN,SOCS1,INSL4,SHC1,GNAS,INS,INS2 |
| protein binding | SAFB,EPHA4,MDH1,RBM25,PDIA6,DSN1,LRDD,PTGDS,NLGN3,RBM15B |
Interacting Protein
IRS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS1.
PIK3R1;PIK3CA
IRS1 Related Signal Pathway
Resources
Research Area
phospho-Serine/phospho-Threonine Binding ProteinsEndocrine Regulation of Lipid Metabolism
Related Services
Related Products
References
- Kim, MJ; Rangasamy, S; et al. Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-alpha-induced insulin resistance. JOURNAL OF NANOBIOTECHNOLOGY 13:-(2015).
- Kitazawa, T; Yoshino, Y; et al. Lopinavir inhibits insulin signaling by promoting protein tyrosine phosphatase 1B expression. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:851-855(2014).
