IRF9
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Official Full Name
interferon regulatory factor 9 -
Overview
Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. -
Synonyms
IRF9;interferon regulatory factor 9;interferon stimulated transcription factor 3, gamma (48kD) , interferon stimulated transcription factor 3, gamma 48kDa , ISGF3G;ISGF-3 gamma;ISGF3 p48 subunit;interferon-stimulated gene factor 3 gamma;transcripti
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
- GST
Involved Pathway
IRF9 involved in several pathways and played different roles in them. We selected most pathways IRF9 participated on our site, such as Cytokine Signaling in Immune system,Hepatitis C,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IFN-gamma pathway | DAPK1 |
| Cytokine Signaling in Immune system | ISG20,LAMTOR2,IL1RN,TAB1,IRF4,CISH,EGR1,IFIT8,KPNA5,DPF1 |
| Influenza A | GSK3B,MAP2K4,MAPK11,IKBKB,TNFRSF10C,OAS3,IL1A,OAS1A,PIK3R2,HLA-DPB1 |
| Immune System | ALCAMB,RNF220,BTR16,CTSH,AP1S1,SIGLEC6,CLEC2G,SEC61B,MYO9B,Mill2 |
| Hepatitis C | OAS3,PPP2R2B,CLDN18,BRAF,TRP53,OSTN,Ifna11,CLDN8,IRF7,PIK3CA |
| Interferon alpha/beta signaling | GBP2,XAF1,IFIT3,IFITM2,IFI35,BST2,SAMHD1,ISG20,IRF6,USP18 |
| Interferon Signaling | IFIT10,ISG20,GBP4,TRIM26,TRIM31,USP18,HERC5,TRIM10,MX2,IFITM2 |
| Herpes simplex infection | SRSF5A,HLA-DQB1,IL15,MED8,CRFB2,BLB2,TLR9,CUL1B,HLA-A,HLA-DRB3 |
Protein Function
IRF9 has several biochemical functions, for example, core promoter binding,protein binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF9 itself. We selected most functions IRF9 had, and list some proteins which have the same functions with IRF9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ZNF45,SIX1B,DRAP1,ZNF234,TBPL2,FOXE3,SIX1,FOXN2,IRF1B,ZNF615 |
| core promoter binding | E2F2,REST,PSPC1,AGO2,SFPI1,ELK4,SPI1,GTF2B,HMGA2,FOXP3 |
| protein binding | STAG3,MRPS27,KRTAP13-3,WBP4,LRRC47,TCTEX1D2,CHMP4A,CCNK,LPXN,NKD2 |
Interacting Protein
IRF9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF9 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF9.
STAT2;IFNAR2;STAT1;MYO1F;uvrA;S100A13;pi3p
IRF9 Related Signal Pathway
Resources
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References
- Erb, HHH; Langlechner, RV; et al. IL6 sensitizes prostate cancer to the antiproliferative effect of IFN alpha(2) through IRF9. ENDOCRINE-RELATED CANCER 20:677-689(2013).
- Colonne, PM; Sahni, A; et al. Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii. JOURNAL OF MEDICAL MICROBIOLOGY 62:968-979(2013).
