INTS6
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Official Full Name
integrator complex subunit 6 -
Overview
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3 end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
INTS6;integrator complex subunit 6;DDX26, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 26;DBI 1;DDX26A;DICE1;HDB;INT6;Notchl2;DBI-1;DBI1;DDX26;DEAD box protein;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 26;Deleted in cancer 1;DKFZp434B105;INT6_HUMAN;INTS 6;OTTHUMP00000018439;OTTHUMP00000215034;OTTHUMP00000215036;Protein DDX26;Protein deleted in cancer 1;RNA helicase HDB;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| INTS6-2479H | Recombinant Human INTS6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| INTS6-481H | Recombinant Human INTS6 Protein, His-tagged | E.coli | Human | His |
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| INTS6-6732Z | Recombinant Zebrafish INTS6 | Mammalian Cells | Zebrafish | His |
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| INTS6-8250M | Recombinant Mouse INTS6 Protein | Mammalian Cells | Mouse | His |
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| INTS6-4570M | Recombinant Mouse INTS6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| INTS6-4570M-B | Recombinant Mouse INTS6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
INTS6 involved in several pathways and played different roles in them. We selected most pathways INTS6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with INTS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
INTS6 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by INTS6 itself. We selected most functions INTS6 had, and list some proteins which have the same functions with INTS6. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
INTS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INTS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of INTS6.
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References
- Zhang, F; Ma, T; et al. A core hSSB1-INTS complex participates in the DNA damage response. JOURNAL OF CELL SCIENCE 126:4850-4855(2013).
- Kapp, LD; Abrams, EW; et al. The Integrator Complex Subunit 6 (Ints6) Confines the Dorsal Organizer in Vertebrate Embryogenesis. PLOS GENETICS 9:-(2013).
