INSL4
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Official Full Name
insulin-like 4 (placenta) -
Overview
INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. -
Synonyms
INSL4;insulin-like 4 (placenta);early placenta insulin-like peptide;EPIL;early placenta insulin like peptide (EPIL);Early placenta insulin like peptide A chain;Early placenta insulin like peptide;Early placenta insulin like peptide B chain;Early placenta insulin-like peptide A chain;INSL4_HUMAN;insulin like 4;insulin like 4 (placenta);Insulin like peptide 4;Insulin-like peptide 4;OTTHUMP00000021025;Placentin;early placenta insulin-like peptide (EPIL)
Recombinant Proteins
- Human
- HEK293
- E.coli
- Human Cells
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- His&GST
- Non
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| INSL4-118H | Recombinant Human INSL4, His-tagged | HEK293 | Human | His | 26-139 a.a. |
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| INSL4-319H | Recombinant Human INSL4 protein(Met1-Thr139), His-tagged | HEK293 | Human | His | Met1-Thr139 |
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| INSL4-723H | Recombinant Human INSL4 Protein, GST-His-tagged | E.coli | Human | His&GST |
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| INSL4-001HCL | Recombinant Human INSL4 cell lysate | Human Cells | Human | Non |
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| INSL4-3117H | Recombinant Human INSL4 Protein (Ala26-Thr139), C-His tagged | Mammalian Cells | Human | His | Ala26-Thr139 |
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| INSL4-5096H | Recombinant Human INSL4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| INSL4-5984HF | Recombinant Full Length Human INSL4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 26-139 amino acids |
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Involved Pathway
INSL4 involved in several pathways and played different roles in them. We selected most pathways INSL4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with INSL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
INSL4 has several biochemical functions, for example, hormone activity,insulin-like growth factor receptor binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSL4 itself. We selected most functions INSL4 had, and list some proteins which have the same functions with INSL4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin-like growth factor receptor binding | INS,SHC1,PIK3R1,ARRB1,SOCS1,SOCS2,YWHAH,YWHAG,INSR,REN |
| receptor binding | NRG1,TNFSF12,ANGPTL2,DAO1,REN,PRDX5,NUDT7,GFRA1,UTS2,TAC4 |
| hormone activity | URP2,Gh,GNRH3,INSL5A,GUCA2A,RETN,PYY,METRNL,PTHLH,FSHB |
Interacting Protein
INSL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSL4.
Resources
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References
- Bruni, L; Luisi, S; et al. Changes in the maternal serum concentration of proearly placenta insulin-like growth factor peptides in normal vs abnormal pregnancy. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 197:-(2007).
- Mock, P; Frydman, R; et al. Expression of Pro-EPIL peptides encoded by the insulin-like 4 (INSL4) gene in chromosomally abnormal pregnancies.. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 85:3941-3944(2000).
