INMT
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Official Full Name
indolethylamine N-methyltransferase -
Overview
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. -
Synonyms
INMT;indolethylamine N-methyltransferase;Amine N methyltransferase;Amine N-methyltransferase;Aromatic alkylamine N methyltransferase;Aromatic alkylamine N-methyltransferase;Arylamine N methyltransferase;Arylamine N-methyltransferase;Indolamine N-methyltransferase;Indolethylamine N methyltransferase;INMT_HUMAN;nicotine N methyltransferase;thioester S methyltransferase like;nicotine N-methyltransferase
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Rat
- Rabbit
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- GST
- His&SUMO
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
INMT involved in several pathways and played different roles in them. We selected most pathways INMT participated on our site, such as Selenocompound metabolism,Tryptophan metabolism,nicotine degradation IV, which may be useful for your reference. Also, other proteins which involved in the same pathway with INMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tryptophan metabolism | CCBL1,TDO2A,AOX1,RNF25,ALDH3A2,ALDH9A1B,GCDHB,HADH,MAOB,HADHAB |
| Selenocompound metabolism | PAPSS1,PAPSS2B,TXNRD2,SCLY,SEPHS2,SEPSECS,TXNRD3,MTR,PAPSS2,TRR1 |
Protein Function
INMT has several biochemical functions, for example, amine N-methyltransferase activity,protein binding,thioether S-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INMT itself. We selected most functions INMT had, and list some proteins which have the same functions with INMT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZBTB4,ZFP932,TBKBP1,RAB39A,CUL5,KIAA1109,ARFIP2,RABL2,MT3,ZNHIT6 |
Interacting Protein
INMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INMT here. Most of them are supplied by our site. Hope this information will be useful for your research of INMT.
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References
- Bashiri, A; Heo, HJ; et al. Pregnancy complicated by obesity induces global transcript expression alterations in visceral and subcutaneous fat. MOLECULAR GENETICS AND GENOMICS 289:695-705(2014).
- Chu, UB; Vorperian, SK; et al. Noncompetitive Inhibition of Indolethylamine-N-methyltransferase by N,N-Dimethyltryptannine and N,N-Dimethylaminopropyltryptamine. BIOCHEMISTRY 53:2956-2965(2014).
