IMPA2
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Official Full Name
inositol(myo)-1(or 4)-monophosphatase 2 -
Overview
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011] -
Synonyms
IMPA2;inositol(myo)-1(or 4)-monophosphatase 2;inositol monophosphatase 2;IMP 2;IMPase 2;inosine monophosphatase 2;myo-inositol monophosphatase A2;inositol monophosphatase 2 variant 1;inositol monophosphatase 2 variant 2
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
IMPA2 involved in several pathways and played different roles in them. We selected most pathways IMPA2 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | INPP5K,IPPK,PIP5K1AB,SYNJ1,MTMR4,PI4KB,IPMK,MINPP1,MTMR8,PIP5K1AA |
| Phosphatidylinositol signaling system | INPP5KA,MTMR7B,PLCB3,PIP5K1BA,TMEM55B,PIP5K1BB,PIK3C2G,PLCD1A,PIK3R3,ITPR1 |
| Metabolic pathways | SAT1A.2,PTGIS,SLC33A1,NDUFS7,ST20-MTHFS,SQLE,CTPS1A,POLR2J3,AKR1B10,IMPDH2 |
Protein Function
IMPA2 has several biochemical functions, for example, inositol monophosphate 1-phosphatase activity,inositol monophosphate 3-phosphatase activity,inositol monophosphate 4-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPA2 itself. We selected most functions IMPA2 had, and list some proteins which have the same functions with IMPA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TIRAP,CADM2A,BAXA,CHUK,HHEX,GM5506,CBS,GPD1L,GZMA,CLIC6 |
| magnesium ion binding | MTHFD2,PRPS1,EPHX2,ENOSF1,PKMA,CIB3,FARSB,NT5C1BA,PPA1A,PGM5 |
| protein binding | HOXB9,BRIP1,HDAC2,KANSL2,ZFP110,KCNIP3,NDFIP2,ARL4C,CD226,TBC1D16 |
| inositol monophosphate 4-phosphatase activity | IMPA1,IMPAD1 |
| inositol monophosphate 3-phosphatase activity | IMPA1,IMPAD1 |
| inositol monophosphate 1-phosphatase activity | IMPA1,IMPAD1 |
Interacting Protein
IMPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPA2.
IMPA1;UBA3;CCT6A;HERPUD1;q8ckm5_yerpe;TNFRSF14
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References
- Ohnishi, T; Murata, T; et al. Defective Craniofacial Development and Brain Function in a Mouse Model for Depletion of Intracellular Inositol Synthesis. JOURNAL OF BIOLOGICAL CHEMISTRY 289:10785-10796(2014).
- Jimenez, E; Arias, B; et al. Genetic variability at IMPA2, INPP1 and GSK3 beta increases the risk of suicidal behavior in bipolar patients. EUROPEAN NEUROPSYCHOPHARMACOLOGY 23:1452-1462(2013).
