Il4ra
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Official Full Name
interleukin 4 receptor, alpha -
Overview
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind;interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to;promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the;membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by;T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as;allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to;human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. -
Synonyms
interleukin 5 (colony-stimulating factor, eosinophil);IL5;IL-5;interleukin 5;TRF;T-cell replacing factor;interleukin-5;eosinophil differentiation factor
Recombinant Proteins
- Mouse
- Human
- Cynomolgus/Rhesus macaque
- Rat
- Mammalian cells
- HEK293
- E.coli
- Mammalian Cell
- Human Cell
- Fc
- His
- His&T7
- Fc&Avi
- His&Fc&Avi
Involved Pathway
Il4ra involved in several pathways and played different roles in them. We selected most pathways Il4ra participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il4ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory bowel disease (IBD) | MAF,IL21R,Il23a,TLR4,HLA-DRB5,IL17A,RORC,SMAD2,HLA-DMA,SMAD3 |
| Cytokine-cytokine receptor interaction | IFNA13,PRLRA,IL29,TGFBR1A,BMP2,PDGFAA,PPBP,NGFR,Ccl21a,LOC100033925 |
| PIK-Akt signaling pathway | G6PC,ITGA9,HGF,PHLPP1,RHEB,EIF4E2,G6PC2,ITGB5,VTN,ITGA7 |
| Jak-STAT signaling pathway | MPL,LEPA,STAT1B,PRL,PIK3R5,IL12RB2,IFNAR1,PIAS4,STAT2,PTPN2B |
| Hematopoietic cell lineage | CR2,HLA-DRA,CD14,CD1B,HLA-DRB3,Flt3l,CD9,GM13305,CR1,CSF1 |
Protein Function
Il4ra has several biochemical functions, for example, cytokine receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il4ra itself. We selected most functions Il4ra had, and list some proteins which have the same functions with Il4ra. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TMEM106B,KATNBL1,FZD5,CUL3,CARM1,HYI,NFKBIL2,TMEM30A,CCDC167,SALL2 |
| cytokine receptor activity | IL20RB,FLT3,IL13RA1,CRFB16,LIFRA,IRX1,PRLRA,IL4R.1,IL15RA,GHRA |
Interacting Protein
Il4ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il4ra here. Most of them are supplied by our site. Hope this information will be useful for your research of Il4ra.
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