IL26
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Official Full Name
interleukin 26 -
Overview
Interleukin 26 (IL-26) is a homodimer cytokine belonging to the IL-10 family that is expressed in certain herpesvirus-transformed T cells but IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3,Which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells. IL-26's function in human disease is unknown, however research has found that IL-26 expression is up-regulated in active Crohn's disease, and therefore may play an active role along with Th17 cells in various autoimmune diseases. -
Synonyms
IL26;interleukin 26;interleukin-26;AK155;IL 26;IL-26
Recombinant Proteins
- Zebrafish
- Human
- Mammalian Cell
- HEK293
- E.coli
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&GST
- His&B2M
- His&Trx
- GST
- N-MBP&C-His-Avi
Involved Pathway
IL26 involved in several pathways and played different roles in them. We selected most pathways IL26 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | GM-CSF,TNFRSF11A,EDAR,CXCL5,CCL3L3,CCR10,GM1987,IL22RA2,IL20RB,CXCL8B.3 |
Protein Function
IL26 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL26 itself. We selected most functions IL26 had, and list some proteins which have the same functions with IL26. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | Ccl12,TNFSF15,Ctf2,IL15,GDF1,BMP5,IL25,IL37,IL31,BMP7B |
Interacting Protein
IL26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL26 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL26.
Resources
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References
- Skepner, J; Ramesh, R; et al. Pharmacologic Inhibition of ROR gamma t Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo. JOURNAL OF IMMUNOLOGY 192:2564-2575(2014).
- Brand, S; et al. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. GUT 58:1152-1167(2009).
