IGF2BP1
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Official Full Name
insulin-like growth factor 2 mRNA binding protein 1 -
Overview
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
IGF2BP1;insulin-like growth factor 2 mRNA binding protein 1;insulin-like growth factor 2 mRNA-binding protein 1;IGF II mRNA binding protein 1;IMP 1;ZBP-1;VICKZ family member 1;zipcode-binding protein 1;IGF2 mRNA-binding protein 1;IGF-II mRNA-bind
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Chicken
- Mouse
- Wheat Germ
- E.coli
- HEK293
- Mammalian Cell
- Insect Cell
- HEK293T
- Mamanlian cells
- Insect cells
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
IGF2BP1 involved in several pathways and played different roles in them. We selected most pathways IGF2BP1 participated on our site, such as BDNF signaling pathway,Gene Expression,Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2BP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | SALL4,TLE4,TLE2,T,BCL9,CDX1,TLE1,AES,CYR61,HBP1 |
| MAPK family signaling cascades | CDC42EP5,CDC42EP1B,CDC42EP2,MAPK4,CDC42EP3,SEPT7,MAPK6 |
| MicroRNAs in cancer | TRP53,DICER1,Casp3,SOCS1,PLAU,BMI1,TNR,RHOA,CCNG1,SOS1 |
| Signal Transduction | BCO2L,RGS7,ARHGAP15,ARHGEF17,STAM2,ARHGAP44,PNOC,FAM13A,CALCB,AXL |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | IGF2BP3,IGF2BP2 |
| MAPK6/MAPK4 signaling | CDC42EP5,CDC42EP3,SEPT7,MAPK4,CDC42EP2,MAPK6,CDC42EP1B |
| Gene Expression | TEAD3B,NFIA,PHF19,ZNF747,TET1,FAUB,UHRF1,ZNF223,ZNF490,ZNF136 |
| BDNF signaling pathway | CDKL5,BCL2L11,DOK5,EIF4EBP1,CSNK2A1P,CSNK2A1,LINGO1,CNR1,SIRPA,JAK2 |
Protein Function
IGF2BP1 has several biochemical functions, for example, mRNA 3-UTR binding,mRNA 5-UTR binding,mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2BP1 itself. We selected most functions IGF2BP1 had, and list some proteins which have the same functions with IGF2BP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mRNA 5-UTR binding | RPS14,MRPS11,DDX3X,IGF2BP3,IGF2BP2,LARP1 |
| mRNA binding | RBM5,CPSF5,CSTF2,CROP,RPL7,DHFR,EDC3,DCP1B,RBPMS2B,HSP26 |
| translation regulator activity | IGF2BP2,YBX2,IGF2BP3,AIRE,RPS9,RPS14 |
| poly(A) RNA binding | NMD3,QK,UTP15,EIF4G2,PRKDC,U2AF1,C14orf93,CDKN2A,TRIP6,SAFB |
| nucleotide binding | SNRNP35,CPEB2,ATP13A,SBK3,PTK2AA,RBM17,IGF1RB,UBE2G1A,EPHB4A,SMC5 |
| protein binding | VHLL,ZNF436,SPANXA1,KLRC4-KLRK1,ANKZF1,UTP23,MSI2,ALCAM,CREB3,KAT2A |
| mRNA 3-UTR binding | PUM2,CSDA,CRYZ,RIMS2,PUM1,CARHSP1,YBX2,LARP1,CPEB4,FXR1 |
Interacting Protein
IGF2BP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2BP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2BP1.
PRKRA;HLA-B;GSK3B;ARHGDIA;CNBP;Ybx1;PSPH;ILK;IKBKE;SMYD2;LYAR;FTSJ1;PUF60;midostaurin;NS1;pre-let-7a
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References
- Lederer, M; Bley, N; et al. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. SEMINARS IN CANCER BIOLOGY 29:3-12(2014).
