IFNK
-
Official Full Name
interferon, kappa -
Overview
This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. -
Synonyms
IFNK;interferon, kappa;interferon kappa;IFN kappa;IFN-kappa;interferon-like protein;RP11-27J8.1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Wheat Germ
- Mammalian Cells
- E.coli
- NS0
- HEK293
- In Vitro Cell Free System
- Yeast
- GST
- His
- Non
- His&Fc&Avi
- C-His-PDI
- His&Myc
- His&GST
- His&SUMO
Involved Pathway
IFNK involved in several pathways and played different roles in them. We selected most pathways IFNK participated on our site, such as Cytokine-cytokine receptor interaction,RIG-I-like receptor signaling pathway,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | Il6ra,LEP,GHRA,PIK3CA,SOCS2,AKT3A,PIAS4A,IL29,IL2RG,IRX1 |
| Cytokine-cytokine receptor interaction | LIF,TNFSF12,IRX1,EDAR,IFNA5,IL22,Cxcl15,GM13306,INHBA,CD40 |
| RIG-I-like receptor signaling pathway | Ifna11,IFNA2,MAPK8A,RIPK1,IKBKE,MAVS,IL12BA,MAPK13,TRAF3,MAPK14B |
Protein Function
IFNK has several biochemical functions, for example, cytokine activity,type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNK itself. We selected most functions IFNK had, and list some proteins which have the same functions with IFNK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| type I interferon receptor binding | GM13288,GM13287,IFNA14,IFNPHI1,Gm13290,IFNA17,OSTN,IFNA16,Ifnz,IFNA1 |
| cytokine activity | INHBA,IL18,TNFSF13B,BMP2B,IFNA8,IL36RN,Ccl9,PRL7D1,CCL38.1,LFT2 |
Interacting Protein
IFNK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNK here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNK.
Resources
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References
- Harley, ITW; Niewold, TB; et al. The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY :-(2010).
