IFNGR2
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Official Full Name
interferon gamma receptor 2 (interferon gamma transducer 1) -
Overview
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008] -
Synonyms
IFNGR2;interferon gamma receptor 2 (interferon gamma transducer 1);AF-1;IFGR2;IFNGT1;interferon gamma receptor 2;IFN-gamma-R2;IFN-gamma receptor 2;interferon gamma transducer 1;interferon gamma receptor beta chain;interferon gamma receptor accessory factor 1;interferon gamma receptor accessory factor-1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- HEK293
- Mammalian cells
- Mammalian Cell
- Human Cell
- Mouse
- Rat
- HEK293T
- CHO
- E.coli expression system
- GST
- His
- Fc
- Non
- Alexa Fluor
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
IFNGR2 involved in several pathways and played different roles in them. We selected most pathways IFNGR2 participated on our site, such as Cytokine-cytokine receptor interaction,HIF- signaling pathway,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leishmaniasis | HLA-DPB1,MAPK11,FCGR4,FCGR1A,HLA-DMA,CR1,IRAK4,HLA-DQA2,MAPK1,MAPK3 |
| Toxoplasmosis | ITGA6,TRAF6,MAPK13,IFNGR1,GNAI3,LAMB1,TGFB1,LDLR,PIK3CG,PIK3R1 |
| Cytokine-cytokine receptor interaction | CCL26,CXCL12A,CNTF,Il23a,PDGFB,IL8L2,IL1RAP,IL1A,GM13305,TNFSF12 |
| Jak-STAT signaling pathway | IL28RA,CCND3,SOCS2,IFNPHI3,GRB2B,IL4,AOX3L1,PIK3R3B,GH1,IL3 |
| Tuberculosis | MYD88,IL1B,PMAP-36,HLA-DRB5,CARD9,RAB5C,RFXANK,TGFB3,IL12B,MAPK1 |
| Influenza A | H2-AB1,IFNA2,TNFRSF1A,CASP1,HLA-DOB,IFNB,LOC100686744,MYD88,TLR7,PIK3CD |
| Herpes simplex infection | IFNA5,UBE2R2,MAPK8A,EP300,CYCSB,POLR2A,CDC34,TLR3,C3A.2,TAP2 |
| Natural killer cell mediated cytotoxicity | PRKCA,H60a,MAPK1,PIK3R3,KIR2DL1,SHC2,PIK3CB,PIK3R1,HRAS,PIK3CG |
| Inflammatory bowel disease (IBD) | TGFB2,NFKB1,IFNGR1,FOXP3,STAT3,IL4R,IL17F,TLR4,HLA-DQB1,IL18 |
Protein Function
IFNGR2 has several biochemical functions, for example, interferon-gamma receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNGR2 itself. We selected most functions IFNGR2 had, and list some proteins which have the same functions with IFNGR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interferon-gamma receptor activity | IFNGR1 |
Interacting Protein
IFNGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNGR2.
IFNGR2 Related Signal Pathway
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