IFNE
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Official Full Name
interferon, epsilon -
Overview
Tau, a microtubulebinding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by glycogen synthase kinase 3 (GSK 3). Cellular and subcellular localization: In situ, anti-tau-1 has a stringent specificity for the axons of neurons. The antibody does not stain the cell bodies or dendrites of neurons, nor does it stain any other cell type (4). However, this in vivo intracellular specificity is not maintained in culture: anti-tau-1 stains the axon, cell bodies, and dendrites of rat hippocampal neurons grown in culture (5). The specificity of anti-tau-1 was originally thought to represent the restricted expression of tau to axons. Later studies revealed that this specificity is dependant on the state of phosphorylation. In dephosphorylated samples (samples treated with alkaline phosphatase) anti-tau-1 stains astrocytes, perineuronal glial cells, and the axons, cell bodies and dendrites of neurons, while in untreated samples, anti-tau-1 stains only axons (6). (The epitope recognized by anti-tau-1 is probably at or near a phosphorylated site.) -
Synonyms
IFNE;interferon, epsilon;interferon epsilon;IFNE1;IFN-epsilon;interferon tau-1;interferon-epsilon;interferon epsilon 1;interferon epsilon-1;IFN-E;IFNT1;PRO655;MGC119018;MGC119020
Recombinant Proteins
- Human
- Mouse
- Horse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Yeast
- In Vitro Cell Free System
- His&T7
- GST
- His
- Non
- His&SUMO
- His&Fc&Avi
Involved Pathway
IFNE involved in several pathways and played different roles in them. We selected most pathways IFNE participated on our site, such as Cytokine-cytokine receptor interaction,RIG-I-like receptor signaling pathway,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I-like receptor signaling pathway | IFIH1,IL12B,NFKBIB,RNF207B,MAP3K7,IFNB1,TP-1,CASP8,IFNB,CXCL8B.3 |
| Cytokine-cytokine receptor interaction | Il2,CCL24,TNFSF13,PF4,CXCR7,XCL2,TNFSF14,CCL21B,IL21R.1,IFNK |
| Jak-STAT signaling pathway | AKT2,PTPN11,IL12RB2,STAT4,PIAS2,LEPB,IFNGR2,IL7,AKT3A,IL19 |
Protein Function
IFNE has several biochemical functions, for example, cytokine activity,type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNE itself. We selected most functions IFNE had, and list some proteins which have the same functions with IFNE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IL17D,Ccl12,IL29,IL12BA,IFNA13,CCL19A.1,IFNPHI4,GRN,IFNB,GDF10 |
| type I interferon receptor binding | IFNPHI3,Ifna11,IFNA14,GM13279,OSTN,GM13288,IFNA10,IFNB1,IFNA1,GM13287 |
Interacting Protein
IFNE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNE here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNE.
Resources
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References
- Guo, YL; Gao, MC; et al. Molecular cloning and characterization of a novel bovine IFN-epsilon. GENE 558:25-30(2015).
- Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
