Ifna4
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Official Full Name
interferon, alpha 4 -
Overview
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by a wide variety of cells types in response to challenges by foreign agents such as viruses, parasites and tumor cells. -
Synonyms
IFNA4;interferon, alpha 4;interferon alpha-4;IFN alpha4a;MGC142200;Interferon alpha 4 precursor;Interferon alpha 4B;Interferon alpha 76;Interferon alpha M1;IFN-alpha-4;interferon alpha-4B;interferon alpha-76;interferon alpha-M1;INFA4;IFN-alpha4a
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- HEK293
- Human Cell
- Mammalian Cell
- E.coli
- Yeast
- Insect Cells
- Insect Cell
- HEK293T
- Fc
- Non
- His
- GST
- mFc
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
Ifna4 involved in several pathways and played different roles in them. We selected most pathways Ifna4 participated on our site, such as Cytokine-cytokine receptor interaction,Regulation of autophagy,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ifna4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis C | PPP2R2B,CLDN8,CLDN9,HRAS,RELA,TP53,CLDN4,IRF1,CLDN6,PPARA |
| Toll-like receptor signaling pathway | TLR3,TLR2-2,CXCL10,IRF5,PIK3CA,NFKBIAB,STAT1B,RIPK1,PIK3R3A,PIK3CB |
| Autoi | IFNA21,IFNA10,HLA-DOB,HLA-DRB5,HLA-DQA2,TSHB,PRF1,HLA-B,CD40LG,HLA-G |
| Jak-STAT signaling pathway | LIFRA,CSH1,PTPN6,MTOR,IL11RA2,IFNW1,IL22RA1,IFNA7,IL12A,IL23 |
| Hepatitis B | MAPK10,TNF,BAX,IFNA12,CASP12,TBK1,TGFB2,YWHAZ,STAT6,CASP8 |
| Cytosolic DNA-sensing pathway | POLR3B,IL33,DDX58,POLR3D,OSTN,CCL4L1,POLR2F,NFKB1,IL18,IFNPHI3 |
| ne thyroid disease | IFNA17,Il2,CD28,H2-Q10,HLA-G,IFNA12,HLA-B,HLA-DOB,IL5,IFNA14 |
| Natural killer cell mediated cytotoxicity | NFATC2,MICB,RAF1,PIK3CD,SOS1,ULBP3,IFNA6,IFNG,TNFSF10,NCR2 |
| RIG-I-like receptor signaling pathway | OTUD5,DHX58,IL8L1,TMEM173,MAPK12A,PIN1,IL12B,NT5C3,ATG5,IKBKG |
Protein Function
Ifna4 has several biochemical functions, for example, cytokine activity,protein binding,type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ifna4 itself. We selected most functions Ifna4 had, and list some proteins which have the same functions with Ifna4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MRE11A,C16orf72,SMG5,PAM,STOX1,BLMH,CXCR4,PPHLN1,INCA1,EP300 |
| cytokine activity | IL4,CSF2,HMGB1B,GDF1,SECTM1,CCL4,IFNPHI4,IL36A,KITLG,HMGB1 |
| type I interferon receptor binding | GM13285,IFNPHI4,IFNA8,IFNA13,IFNA16,IFNA1,IFNB1,GM13287,IFNA3,IFNA17 |
Interacting Protein
Ifna4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ifna4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ifna4.
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References
- Park, JH; Joo, CK; et al. Comparative Study of Tacrolimus and Bevacizumab on Corneal Neovascularization in Rabbits. CORNEA 34:449-455(2015).
- Aydinoglu-Candan, O; Araz-Ersan, B; et al. Anti-interferon alpha antibodies and autoantibodies in patients with Beh double dagger et's disease uveitis treated with recombinant human interferon alpha-2a. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 253:457-465(2015).
