IFI30
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Official Full Name
IFI30 interferon, gamma-inducible protein 30 [ Homo sapiens ] -
Overview
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. -
Synonyms
interferon, gamma-inducible protein 30;5398;Ensembl:ENSG00000216490;MGC32056;gamma-interferon-inducible lysosomal thiol reductase;legumaturain;gamma-interferon-inducible protein IP-30;interferon gamma-inducible protein 30 preproprotein;GILT;IP30;IFI-30
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Human Cell
- HEK293T
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
IFI30 involved in several pathways and played different roles in them. We selected most pathways IFI30 participated on our site, such as Adaptive Immune System,Antigen processing and presentation,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFI30 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MHC class II antigen presentation | KIFAP3,KIF11,KIF3B,OSBPL1A,CTS7,FAM49BA,DCTN6,ACTR1B,KIF26A,KIF22 |
| Cytokine Signaling in Immune system | CRK,FGF18B,PRLRB,DUSP7,IFI35,EIF4E3,EIF4G2A,ISG20,LGALS9,IL1RN |
| Adaptive Immune System | OSBPL1A,FAM49BA,AP1S1,RNF34,KIF26A,KIF2B,PIK3AP1,DNM2,GRAP2A,TREML1 |
| Interferon Signaling | IFIT10,GBP2,TRIM6,ARIH1,BST2,EIF4E3,IFIT2,IFIT8,TRIM29,USP18 |
| Antigen processing and presentation | KLRC3,RFX5,HSPA8,KIR3DL1,HLA-F,TAP1,HLA-DPB1,HLA-DQA2,HLA-DRA,CTSB |
| Interferon gamma signaling | GBP4,TRIM3,GBP1,TRIM10,TRIM2,IRF6,GBP5,TRIM62,TRIM48,OASL |
| Immune System | SPSB2,RNF25,KIF2C,ASB6,KIF5B,ARIH2,DEFB121,TRIM31,KIF3C,DZIP3 |
Protein Function
IFI30 has several biochemical functions, for example, oxidoreductase activity, acting on a sulfur group of donors,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFI30 itself. We selected most functions IFI30 had, and list some proteins which have the same functions with IFI30. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SUGT1,TGM2,RAD54L,CORO1A,SYTL4,RSPH1,TOP1,POMGNT1,IRF5,TSPO |
| oxidoreductase activity, acting on a sulfur group of donors | SRX1 |
Interacting Protein
IFI30 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFI30 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFI30.
NOTCH2NL;KRTAP4-12;mutT7;DAPK1;Cnot2;KIFAP3;Sept6
Resources
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References
- Cheluvappa, R; Eri, R; et al. Modulation of Interferon Activity-Associated Soluble Molecules by Appendicitis and Appendectomy Limits Colitis-Identification of Novel Anti-Colitic Targets. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 35:108-115(2015).
- Metsalu, T; Viltrop, T; et al. Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta. EPIGENETICS 9:1397-1409(2014).
