IDH3A
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Official Full Name
isocitrate dehydrogenase 3 (NAD+) alpha -
Overview
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong;to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five;isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the;mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other;predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated;rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha;subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one;isozyme of NAD(+)-dependent isocitrate dehydrogenase. -
Synonyms
IDH3A;isocitrate dehydrogenase 3 (NAD+) alpha;isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial;H IDH alpha;isocitrate dehydrogenase (NAD+) alpha chain;isocitrate dehydrogenase [NAD] subunit alpha;mitochondrial;isocitric dehydrogenase;NAD(H) specific isocitrate dehydrogenase alpha subunit;NAD+ specific ICDH;EC 1.1.1.41;HIDH alpha;IDH3A_HUMAN;Isocitrate dehydrogenase (NAD+) alpha chain precursor;Isocitrate dehydrogenase [NAD] subunit alpha mitochondrial;Isocitrate dehydrogenase;Isocitric dehydrogenase subunit alpha;NAD;NAD(+)-specific ICDH subunit alpha;NAD(H) specific isocitrate dehydrogenase alpha subunit precursor;NADsubunit alpha mitochondrial precursor;OTTHUMP00000184906;H-IDH alpha;NAD+-specific ICDH;NAD(H)-specific isocitrate dehydrogenase alpha subunit
Recombinant Proteins
- Zebrafish
- Chicken
- Rhesus macaque
- Human
- Rat
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
IDH3A involved in several pathways and played different roles in them. We selected most pathways IDH3A participated on our site, such as Citrate cycle (TCA cycle),Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biosynthesis of amino acids | TKTL1,ENO2,PKM2,MAT2B,SHMT2,TPI1,CTH,RPIA,ALDOB,TKTB |
| Metabolic pathways | DHDPSL,UCK2A,AGPAT6,CYP2C70,CKB,PLCG1,PDXK,MTMR2,SDS,ST20-MTHFS |
| Carbon metabolism | PGP,GLUD1B,PGAM1B,SUCLG1,ACSS2,PGLS,ENO2,SDHB,GLUD2,pykF |
| Citrate cycle (TCA cycle) | SDHB,DLDH,ACO2,SUCLA2,IDH3G,FH,IDH3B,MDH1AA,ACO1,OGDHA |
| -Oxocarboxylic acid metabolism | GPT2L,BCAT2,GOT2,GOT2A,IDH1,ACO2,GOT2B,BCAT1,IDH3G,ACO1 |
Protein Function
IDH3A has several biochemical functions, for example, NAD binding,isocitrate dehydrogenase (NAD+) activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH3A itself. We selected most functions IDH3A had, and list some proteins which have the same functions with IDH3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | UGDH,IDH1,MDH1,TESCA,IDH3B,ME3,DLD,ME1,GPD1A,GRHPRA |
| isocitrate dehydrogenase (NAD+) activity | IDH3G,IDH3B |
| magnesium ion binding | PGM2,PTENB,PPM1AA,MAPK12,ITPK1A,ATP11C,RPS6KA4,PTENA,IMPA1,NCS1 |
Interacting Protein
IDH3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH3A here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH3A.
IDH3B;IDH3G;adp;DMWD;DDA1;IKBKG;RAB4A;glgA;MBNL1;MYC;gag-pol
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References
- Chen, XH; Wei, P; et al. A Novel Carbonyl Reductase with Anti-Prelog Stereospecificity from Acetobacter sp CCTCC M209061: Purification and Characterization. PLOS ONE 9:-(2014).
- Yang, C; Fan, J; et al. The role of NAD(+)-dependent isocitrate dehydrogenase 3 subunit alpha in AFB(1) induced liver lesion. TOXICOLOGY LETTERS 224:371-379(2014).
