ID1

  • Official Full Name

    inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

  • Overview

    The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the;basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit;the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may;play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have;been found for this gene.

  • Synonyms

    ID1;inhibitor of DNA binding 1, dominant negative helix-loop-helix protein;DNA-binding protein inhibitor ID-1;bHLHb24;dJ857M17.1.2;DNA binding protein inhibitor ID 1;DNA binding protein inhibitor ID1;Dominant negative helix loop helix protein;ID 1;ID;Inhibitor of Differentiation 1;Inhibitor of DNA binding 1;OTTHUMP00000030534;OTTHUMP00000030535;class B basic helix-loop-helix protein 24;dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi&Fc&His
  • DDK&Myc
  • His&SUMO
  • Flag

    Involved Pathway

    ID1 involved in several pathways and played different roles in them. We selected most pathways ID1 participated on our site, such as Rap signaling pathway,TGF-beta signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ID1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway PIK3R2,RAC1,TEK,PGF,MAPK13,RASGRP3,HRAS,PDGFRB,RRAS,PFN2
    TGF-beta signaling pathway GDF7,NOG3,TGFBR1B,TGIF1,FST,ZFYVE9,RHOAA,BMPR1BB,SMAD4,ID2A
    Signaling pathways regulating pluripotency of stem cells APC,KRAS,FGFR3,MAPK13,OTX1,ZIC3,PCGF2,PIK3R2,STAT3,PIK3CD
    Hippo signaling pathway ITGB2L,SCRIB,WNT7A,PARD6A,YWHAG,WNT16,WTIP,PPP2CA,TEAD4,BMP5

    Protein Function

    ID1 has several biochemical functions, for example, proteasome binding,protein C-terminus binding,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ID1 itself. We selected most functions ID1 had, and list some proteins which have the same functions with ID1. You can find most of the proteins on our site.

    Function Related Protein
    protein homodimerization activity SLC22A6,KCNN2,ATPIF1,FAM109A,MYO7A,TERT,SYT14,ANXA1,PDZD7,IKZF3
    protein N-terminus binding STX1A,PDCD10,ZWINT,BIRC2,NBN,TP53,GLRX,KCNB1,DAXX,TSC1
    protein binding CMKLR1,PUM2,PSMD5,BAI2,THOC1,MOXD1,TEAD4,FKBP6,INADL,ORMDL3
    protein C-terminus binding ZBTB16,VGLL1,PEX5,KCNIP3,CEP135,PHB2,AGO2,XRCC5,PEX16,PCGF1
    transcription factor binding NLK,LCOR,FOSB,WWP2,RELA,MED12L,RNF4,GPX3,SP100,MED6
    proteasome binding BAG6,PSMG1,USP13,DNAJB2,UBD,USP14,ADRM1,UCHL5,PSMF1,PSMD14

    Interacting Protein

    ID1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ID1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ID1.

    CAV1;CASK;APPL1;PSMD4;SUV39H1;TCF4;TCF3;COPB1;COL12A1;TCF3;PIAS1

    Resources

    Research Area

    Transcription Regulators in VSMC
    Cancer Stem Cell Transcription Factors
    Melanoma Biomarkers

    References

    • Bordbar, B; Ndam, NT; et al. Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: Impact on vaccine design for placental malaria. INFECTION GENETICS AND EVOLUTION 25:81-92(2014).
    • Gnidehou, S; Doritchamou, J; et al. Functional Antibodies against VAR2CSA in Nonpregnant Populations from Colombia Exposed to Plasmodium falciparum and Plasmodium vivax. INFECTION AND IMMUNITY 82:2565-2573(2014).

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