HTR4
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 4 -
Overview
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. -
Synonyms
HTR4;5-hydroxytryptamine (serotonin) receptor 4;5-hydroxytryptamine receptor 4;5 HT4;5 HT 4;5 HT4R;5 hydroxytryptamine 4 receptor;5 hydroxytryptamine receptor 4;5 hydroxytryptamine serotonin receptor 4;5 hydroxytryptamine4 receptor;5H4;5HT 4;5HT4;5HT4R;Cardiac 5 HT4 receptor;HTR 4;Serotonin 5 HT4 receptor;Serotonin receptor 4;OTTHUMP00000160384;OTTHUMP00000224250;OTTHUMP00000224252;OTTHUMP00000224254;OTTHUMP00000224281;OTTHUMP00000224282;OTTHUMP00000224307;OTTHUMP00000235919;cardiac 5-HT4 receptor;5-HT4;5-HT4R
Recombinant Proteins
- Human
- Rat
- Mouse
- Guinea pig
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
HTR4 involved in several pathways and played different roles in them. We selected most pathways HTR4 participated on our site, such as Calcium signaling pathway,cAMP signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | PTGER2A,MCHR2,P2RY1,TRHRB,GRIN3B,TAAR14A,PTGER4C,Chrng,SSTR1,P2RY6 |
| Serotonergic synapse | NRAS,HTR5A,GNB2,CYP2J6,CYP2C39,GNG8,GNG13,GNAS,CYP2C70,GNGT1 |
| cAMP signaling pathway | ROCK2,PIK3CG,PDE4C,PTGER2,VAV1,MC2R,CALML5,ATP1B4,FSHB,CAMK2B |
| Calcium signaling pathway | MYLK3,SLC8A3,CYSLTR1,PPIFB,Adcy4,ATP2A1L,PLCB2,STIM1,PRKCG,CACNA1H |
Protein Function
HTR4 has several biochemical functions, for example, serotonin receptor activity,NOT trace-amine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR4 itself. We selected most functions HTR4 had, and list some proteins which have the same functions with HTR4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serotonin receptor activity | HTR1B,HTR5A,HTR1AA,HTR5AL,HTR3C,HTR3A,HTR1D,HTR2B,HTR1AB,HTR1F |
Interacting Protein
HTR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR4.
serotonin;gr 113808;ADRB2
Resources
Research Area
Neurotransmitter Receptors on Endothelial CellsNeurotransmitter G Protein-Coupled Receptors
5-HT Receptors
Related Services
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References
