HSPD1
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Official Full Name
heat shock 60kDa protein 1 (chaperonin) -
Overview
Heat Shock Protein 60 (HSP60) is a chaperonin with roles in mitochondrial protein import and folding of polypeptides in the mitochondrial matrix. -
Synonyms
HSPD1;heat shock 60kDa protein 1 (chaperonin);heat shock 60kD protein 1 (chaperonin) , spastic paraplegia 13 (autosomal dominant) , SPG13;60 kDa heat shock protein, mitochondrial;GROEL;HSP60;chaperonin 60;60 kDa chaperonin;heat shock protein 65
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- MBP
- GST
- T7
- Avi
- Fc
Involved Pathway
HSPD1 involved in several pathways and played different roles in them. We selected most pathways HSPD1 participated on our site, such as RNA degradation,Type I diabetes mellitus,Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Legionellosis | C3,Itgam&Itgb2,NAIP6,IL1B,NLRC4,SAR1B,HSPA1B,SEC22B,HSPA1A,HSPA8 |
| Tuberculosis | CAP18,IFNA8,BCL2,H2-AB1,IL1A,MRC2,MAPK13,CAMP,APAF1,CAMK2G |
| Type I diabetes mellitus | IL1A,HLA-DRB4,HLA-DRB3,GZMB,H2-AB1,HLA-B,HLA-DMB,HLA-DRA,HLA-DRB5,GAD1 |
| RNA degradation | DCPS,PFKP,WDR61,LSM4,MPHOSPH6,LSM8,LSM2,EDC4,EXOSC5,SKIV2L |
Protein Function
HSPD1 has several biochemical functions, for example, ATP binding,ATPase activity,DNA replication origin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPD1 itself. We selected most functions HSPD1 had, and list some proteins which have the same functions with HSPD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA replication origin binding | ORC3L,ORC2L,MCM5,ORC4,CDC45,ORC4L,MCM10,MCM2 |
| protein binding | NUDT2,CDK5RAP3,C10orf28,MAP4K4,NUDT16L1,CENPI,ENTPD5,TRIM67,CCNL1,CRADD |
| unfolded protein binding | HSP90AB1,HSPA2,CCT2,TUBB4B,TMEM67,PFDN5,GRXCR2,TCP1,DNAJB1A,SRSF10 |
| double-stranded RNA binding | OAS3,STAU1,TFRC,OASL2,STAU2,RNASEN,MSN,TUBB4B,DROSHA,DHX15 |
| ATP binding | CMPK1,KIFC2,ABCD2,CDK20,FUK,NARS,ATAD1,IRAK4,PRKCD,CHD1L |
| poly(A) RNA binding | DNM1,EIF4E,NCBP1,RBM26,DDX47,RBM22,ZCCHC6,RPUSD2,NOL6,EIF3C |
| protein complex binding | TULP3,DRD1,COG2,RAP1B,PAFAH1B1,VDAC1,ATG101,NDUFA9,FYB,INS2 |
| protein heterodimerization activity | AGTR1A,TGFB3,GAD2,PPP3CA,DRD2,HIST1H4H,ADD1,CHRAC1,ENO2,KCNK9 |
| ATPase activity | ABCG2A,OLA1,KIF2A,KIF4A,MLH1,ABCF1,ABCG4B,PSMC1,ATAD2B,ERCC3 |
Interacting Protein
HSPD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPD1.
LZTS2;Smpd3;FHIT;RGS20;RGS20
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References
- Hjelholt, A; Carlsen, T; et al. Increased Levels of IgG Antibodies against Human HSP60 in Patients with Spondyloarthritis. PLOS ONE 8:-(2013).
- Kreutmayer, S; Csordas, A; et al. Chlamydia pneumoniae infection acts as an endothelial stressor with the potential to initiate the earliest heat shock protein 60-dependent inflammatory stage of atherosclerosis. CELL STRESS & CHAPERONES 18:259-268(2013).
