HSPB1
-
Official Full Name
heat shock 27kDa protein 1 -
Overview
Heat shock proteins (HSP) are a class of functionally related proteins whose expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of theheat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. -
Synonyms
Heat shock protein;HSP;THR-PHE-GLY-LEU-GLN-LEU-GLU-LEU-THR;H-THR-PHE-GLY-LEU-GLN-LEU-GLU-LEU-THR-OH;HEAT SHOCK PROTEIN, 65 KD, MYCOBACTERIUM BOVIS BCG, FRAGMENT 180-188;HEAT SHOCK PROTEIN, 65KD, MYCOBACTERIUM BOVIS BCG;SNP nonapeptide
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Cattle
- E.coli
- Mammalian Cells
- S.frugiperda
- Wheat Germ
- HEK293
- Mouse
- Rabbit
- In Vitro Cell Free System
- GST
- His
- Non
- His&MBP
- His&T7
- DDK&Myc
- Avi&Fc&His
- Flag
Involved Pathway
HSPB1 involved in several pathways and played different roles in them. We selected most pathways HSPB1 participated on our site, such as MAPK signaling pathway,VEGF signaling pathway,Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amoebiasis | SERPINB1C,PIK3R3,COL2A1,TLR2,RAB7A,CD14,Itgam&Itgb2,PIK3R2,SERPINB2,GM-CSF |
| Epstein-Barr virus infection | TBPL1,PLCG2,H2-Q10,GTF2B,POLR1D,PIK3CG,HLA-DQB1,POLR2C,POLR2F,POLR3GL |
| MAPK signaling pathway | HSPA6,PLA2G4F,HSPA8,PPP3CC,MAPK8,MAPK10,MAP2K2,CDC42L2,PPP3CCB,PDGFA |
| VEGF signaling pathway | HRAS,PPP3CA,MAPK3,PRKCA,PTK2,RAC2,PLCG2,MAP2K1,RAC1A,PLA2G4C |
Protein Function
HSPB1 has several biochemical functions, for example, identical protein binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPB1 itself. We selected most functions HSPB1 had, and list some proteins which have the same functions with HSPB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | PDCD10,AP1B1,PTPRK,HIF1A,RPTOR,NPM1,PAX6,SREBF1,MAP3K1,NEK6 |
| ubiquitin binding | OTUB1B,BRAP,UBXN11,TSG101,NSFL1C,UBAP1,PER2,NUP62,TOP2A,KIF18A |
| protein kinase C inhibitor activity | YWHAG,SFN |
| identical protein binding | GCG,TRAF6,CLDN15,SERPINB1A,RBM10,COL1A2,CASC3,CLPP,PARK7,STAT2 |
| protein binding | IGSF8,C7orf59,HFE2,CREB3L1,TMPO,GLS,WWTR1,PUM2,CFL1,AP3S1 |
| protein kinase C binding | PEA15A,PRKCB,HDAC7,IRS1,C1QBP,DACT2,AVPR1B,HDAC9,TOP2A,ADD3 |
| poly(A) RNA binding | ZFML,MRPL2,RBM10,TMEM38A,CASC3,FSCN1,DDX39B,MKI67IP,MYBBP1A,RPL7L1 |
Interacting Protein
HSPB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPB1.
BAG3;CRYAB;TP53;YWHAZ;EGFR
Resources
Research Area
Cancer Drug TargetsDiabetic Peripheral Neuropathy
Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
Intracellular Signaling Molecules in Angiogenesis
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References
- Ding, YB; Yang, M; et al. iTRAQ-based quantitative proteomic analysis of cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1748-1758(2015).
- Gulyas, G; Czegledi, L; et al. PROTEOMIC ANALYSIS OF SKELETAL MUSCLE AT DIFFERENT LIVE WEIGHTS IN CHAROLAIS BULLS. ACTA ALIMENTARIA 44:132-138(2015).
