HSPA4
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Official Full Name
heat shock 70kDa protein 4 -
Overview
Heat shock proteins (HSPs) are an important part of the cell's machinery for protein folding and help to protect cells from stress. HSPs are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing some cells to survive near lethal conditions. HSPs are expressed in tumor cell proliferation, differentiation, invasion and metastasis. In addition to improving overall protein integrity, HSP70 directly inhibits apoptosis, and has been shown to be involved in a protective role against thermal stress and cytotoxic drugs. Recently HSP70 has been reported as a prognostic marker in breast, prostate, lung and liver cancer patients -
Synonyms
HSPA4;heat shock 70kDa protein 4;heat shock 70kD protein 4;heat shock 70 kDa protein 4;HS24/P52;hsp70 RY;HSPH2;heat shock protein, 110 kDa;heat shock 70-related protein APG-2;RY;APG-2;hsp70;hsp70RY;MGC131852
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- GST
- Myc&DDK
- His&T7
- Non
- His
- His&Fc&Avi
- Flag
Involved Pathway
HSPA4 involved in several pathways and played different roles in them. We selected most pathways HSPA4 participated on our site, such as Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | CTSL1,HLA-DPA1,HLA-DRB1,KLRC2,HLA-DMA,CD74,HSPA1A,HLA-DQB1,HSPA2,HSPA1B |
Protein Function
HSPA4 has several biochemical functions, for example, ATP binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA4 itself. We selected most functions HSPA4 had, and list some proteins which have the same functions with HSPA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | FGFR3,PHKG1,KIF14,GCLC,TK2,PIP4K2B,NPR2,TOR1L3,TWF2,PET112L |
| protein binding | DCTN5,RTP2,RNF216,WAC,PRRC1,HEYL,IKZF2,MCPH1,DRD3,DPM3 |
Interacting Protein
HSPA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA4.
AGTRAP;APPBP2;EGFR;P;HSPA8;YWHAZ;TRAF2;TAB1;MAP3K3;GAMMAHV.ORF40;PRSS23;HSPB1;CDC73
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