HSD17B10
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Official Full Name
hydroxysteroid (17-beta) dehydrogenase 10 -
Overview
Mutations in several genes associated with early onset Alzheimer’s result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer’s disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer’s disease. -
Synonyms
HSD17B10;hydroxysteroid (17-beta) dehydrogenase 10;HADH2, hydroxyacyl Coenzyme A dehydrogenase, type II, hydroxyacyl Coenzyme A dehydrogenase, type II , mental retardation, X linked, syndromic 10 , MRXS10;3-hydroxyacyl-CoA dehydrogenase type-2;17b HSD10;AB binding alcohol dehydrogenase;ABAD;CAMR;ERAB;MHBD;MRPP2;SDR5C1;short chain dehydrogenase/reductase family 5C;member 1;type 10 17b HSD;type 10 17beta hydroxysteroid dehydrogenase;AB-binding alcohol dehydrogenase;mitochondrial ribonuclease P protein 2;3-hydroxy-2-methylbutyryl-CoA dehydrogenase;short chain type dehydrogenase/reductase XH98G2;amyloid-beta peptide binding alcohol dehydrogenase;short chain L-3-hydroxyacyl-CoA dehydrogenase type 2;short chain dehydrogenase/reductase family 5C, member 1;endoplasmic reticulum-associated amyloid beta-peptide-binding protein;HCD2;HADH2;MRX17;MRX31;SCHAD;MRXS10;17b-HSD10;DUPXp11.22
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rhesus macaque
- Cynomolgus
- Rat
- E.coli
- Mammalian Cell
- Human
- Wheat Germ
- Sf9 Insect Cell
- HEK293
- HEK293T
- Yeast
- Mammalian cells
- In Vitro Cell Free System
- His&T7
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
- Flag
- His&SUMO
Involved Pathway
HSD17B10 involved in several pathways and played different roles in them. We selected most pathways HSD17B10 participated on our site, such as Valine, leucine and isoleucine degradation,Metabolic pathways,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | ATP2A2,CDK5,COX4I2,SDHC,CALML3,NDUFS7,APBB1,IL1B2,NDUFB3,ITPR1 |
| Metabolic pathways | GUSB,PLA2G12A,PNLIPRP3,CYP2C8,MTHFD1B,ADKB,AGPHD1,GDA,AANAT1,GLULC |
| Valine, leucine and isoleucine degradation | ALDH1B1,ALDH9A1A.1,HADHAA,IL4I1,MUT,ALDH2.2,AOX1,ACSF3,ALDH6A1,BCAT2 |
Protein Function
HSD17B10 has several biochemical functions, for example, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity,3-hydroxyacyl-CoA dehydrogenase activity,NAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B10 itself. We selected most functions HSD17B10 had, and list some proteins which have the same functions with HSD17B10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| estradiol 17-beta-dehydrogenase activity | HSD17B12A,HSD17B6,H2-KE6,RDH8B,HSD17B2,HSD17B11,AKR1C6,AKR1B15,HSD17B12B,RDH8A |
| estrogen receptor binding | ARRB1,NKX3-1,PPARGC1A,CTNNB1,NKX3,FOXL2,DDX17,DDX5,TAF10,PADI2 |
| protein binding | HBP1,ARL11,ADRBK1,MCRS1,PAPOLA,KISS1R,ZBTB6,CNTNAP4,PGLS,PARVG |
| identical protein binding | PRDX1,TTR,KDM6A,SF1,SOX10,C1QTNF9,MNS1,GYPA,ATXN3,PYDC3 |
| beta-amyloid binding | IDE,APOA1,CLSTN1,ARMCX5-GPRASP2,ACHE,APOE,TM2D1,HBA-A2,LDLRAD3,APOEB |
| 3-hydroxyacyl-CoA dehydrogenase activity | EHHADH,HADHB,HADHA,HADHAA,HSD17B8,HADHAB,HSD17B4,HADH,H2-KE6 |
| NAD binding | NDUFV1,IDH2,GAPDH,MDH1,GPD1A,CYB5R3,HIBADH,BDH2,HADHA,CTBP2A |
| poly(A) RNA binding | MYEF2,PCBP2,PLEC,C11orf68,MTHFSD,PRPF31,KIAA1429,RPS14,YTHDF1,KPNA2 |
| steroid binding | CYP21A2,Ar,ESR2B,PAQR5,CYP21A1,GPR30,PAQR5A,CYP3A4,PDIA2,PAQR8 |
Interacting Protein
HSD17B10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B10 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B10.
APP;TRMT10C;mt-trna_tyr_rna;KIAA0391;HTRA2;UBE2D1;CHD3;q7cie3_yerpe;FAF1;Srp72;NOP56;GABARAP
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