HPGD
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Official Full Name
hydroxyprostaglandin dehydrogenase 15-(NAD) -
Overview
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HPGD;hydroxyprostaglandin dehydrogenase 15-(NAD);15-hydroxyprostaglandin dehydrogenase [NAD(+)];SDR36C1;short chain dehydrogenase/reductase family 36C;member 1;prostaglandin dehydrogenase 1;NAD+-dependent 15-hydroxyprostaglandin dehydrogenase;shor
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Cynomolgus
- E.coli
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
HPGD involved in several pathways and played different roles in them. We selected most pathways HPGD participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPGD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | PROM1,SIX1,HOXA9,ELANE,HIST1H3I,TFE3,REL,IL6,HIST3H3,SPI1 |
Protein Function
HPGD has several biochemical functions, for example, 15-hydroxyprostaglandin dehydrogenase (NAD+) activity,NAD binding,NAD+ binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPGD itself. We selected most functions HPGD had, and list some proteins which have the same functions with HPGD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TNNC1,TBC1D22A,HMGCS1,MYH9,FAP,EVLA,SMAGP,ABCB9,SLC14A2,NCR3 |
| NAD binding | ADH4,HSD11B2,GAPDH,IDH3G,DLD,GPD1L,AOX3L1,UGDH,ADH1,IDH1 |
| NAD+ binding | HADH,SIRT5,SIRT1,UXS1,SIRT2,SIRT4,ALDH1A3,GLUD1,SIRT7,SIRT6 |
| catalytic activity | QDPRB1,GAD1B,TIGARB,PNP4B,PKMB,NDUFA9A,LYZ1,ACSL1,ALDOCA,GLULB |
| prostaglandin E receptor activity | PTGER4B,PTGER1A,PTGER3,PTGER1B,PTGER2,PTGER2A,PTGER1,PTGER4A,PTGER4,PTGER4C |
Interacting Protein
HPGD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPGD here. Most of them are supplied by our site. Hope this information will be useful for your research of HPGD.
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