HOMER3
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Official Full Name
homer homolog 3 (Drosophila) -
Overview
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants. -
Synonyms
HOMER3;homer homolog 3 (Drosophila);homer protein homolog 3;HOMER 3;HOME3_HUMAN;Homer 3D protein;Homer neuronal immediate early gene 3;Homer-3;VESL3;Homer, neuronal immediate early gene, 3
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
HOMER3 involved in several pathways and played different roles in them. We selected most pathways HOMER3 participated on our site, such as FoxO signaling pathway,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HOMER3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | GRM2,SLC1A6,PRKACG,GNB3,GLS2,GNG11,PRKCG,GRM7,SHANK1,GNG5 |
| FoxO signaling pathway | PTENB,MAPK14B,IKBKB,S1PR4,MAPK8A,SMAD3,INSRB,MAPK12B,MAPK12,HRASB |
Protein Function
HOMER3 has several biochemical functions, for example, G-protein coupled glutamate receptor binding,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOMER3 itself. We selected most functions HOMER3 had, and list some proteins which have the same functions with HOMER3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | PRKAR2B,OCLN,STX1B,YWHABA,BASP1,MED12,ICAL1,CALM1,ARL1,TRIM11 |
| G-protein coupled glutamate receptor binding | HOMER1B,HOMER1,HOMER2 |
| protein C-terminus binding | YWHAB,MAP2K1,CSK,SP1,AP2A1,PPP1R9B,XRCC4,TERF2,ATF4,MID1IP1 |
| protein binding | R3HDM2,TLE3,NOD1,GTF2I,AGFG1,STX5,SPHK1,GDI1,BCL9,TOE1 |
Interacting Protein
HOMER3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOMER3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOMER3.
FAT1;Snw1;APP;ABI3;q9wmx2-pro_0000037548;SRPK2;Cdc16;FRYL;MOS;ul34_ebvb9;gp350_ebvb9;GN
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References
- Mizutani, A; Kuroda, Y; et al. Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. JOURNAL OF NEUROSCIENCE 28:5369-5382(2008).
