HNRNPL
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Official Full Name
heterogeneous nuclear ribonucleoprotein L -
Overview
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
HNRNPL;heterogeneous nuclear ribonucleoprotein L;HNRPL;hnRNP-L;P/OKcl.14;hnRNP L
Recombinant Proteins
- Rhesus macaque
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- His&Fc&Avi
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HNRNPL-2127R | Recombinant Rhesus monkey HNRNPL Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| HNRNPL-4905H | Recombinant Human HNRNPL Protein, GST-tagged | Wheat Germ | Human | GST |
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| HNRNPL-5441HCL | Recombinant Human HNRNPL 293 Cell Lysate | HEK293 | Human | Non |
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| HNRNPL-1414H | Recombinant Human HNRNPL Protein (89-335 aa), His-tagged | Yeast | Human | His | 89-335 aa |
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| HNRNPL-1948R | Recombinant Rhesus Macaque HNRNPL Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| HNRNPL-1948R-B | Recombinant Rhesus Macaque HNRNPL Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| HNRNPL-3616HF | Recombinant Full Length Human HNRNPL Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 558 amino acids |
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| HNRNPL-558H | Recombinant Human HNRNPL Protein (89-335 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 89-335 aa |
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| HNRNPL-559H | Recombinant Human HNRNPL Protein (1-589 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-589 aa |
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Involved Pathway
HNRNPL involved in several pathways and played different roles in them. We selected most pathways HNRNPL participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | KRBA1,PEAK1,METTL14,ZNF573,EIF1AX,RRP8,ZNF70,PTRFB,TH1L,ZNF771 |
| mRNA Splicing - Major Pathway | SF3B2,PTBP1A,CD2BP2,PTBP1B,HNRNPH2,DNAJC8,HNRNPA0B,HNRNPA0A,HNRNPA0L,HNRNPD |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPR,METTL3,SNRNP48,HNRNPUL1,CSTF1,PRPF8,PAPOLA,SLBP,YBX1,HNRNPA0A |
| mRNA processing | SPOP,ZFP830,RNASET2B,METTL3,PRPF4B,SF3A3,SF3A1,VPRBP,CELF2,SRPK2 |
| mRNA Splicing | SF3B4,SF3A3,HNRNPA2B1,TXNL4A,CD2BP2,ZCRB1,HNRNPH2,HNRNPD,RBM5,SFRS3A |
Protein Function
HNRNPL has several biochemical functions, for example, RNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPL itself. We selected most functions HNRNPL had, and list some proteins which have the same functions with HNRNPL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | NR5A2,ZBTB14,MSX2,ZNF567,CCNT1,GLI1,SREBF1,CBX4,BCL11AB,HNF1A |
| nucleotide binding | ACTG2,CELF3A,AKT3A,PPIP5K2,PKZ,RBM3,STK25A,ATP1A3A,NMRK2,RRP7A |
| poly(A) RNA binding | DKC1,D19BWG1357E,HSP90AA1,QKI,AKAP8L,ZFML,ATP5A1,KHDRBS3,MRPS23,MRPS21 |
| RNA binding | EIF4B,MRPL23,NCL,RANBP2,MTHFSD,THOC5,HNRNPU,DKC1,EIF2S1B,TRIM71 |
| protein binding | MRPL23,SNAP47,TLX2,TSGA10,VMP1,IRF3,ZRANB1,CEACAM6,LRRC8C,ANKRD45 |
Interacting Protein
HNRNPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPL here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPL.
YBX1;CSNK2A1;4505953;SGK1;DFFA;CFLAR;SSSCA1;RARA;YWHAZ;ILK;EIF2B1;DOCK4;TNFRSF14;ZNF143;TMBIM4;SMYD2;PUF60;TRAF6
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References
- Lee, DH; Lim, MH; et al. hnRNP L binds to CA repeats in the 3 ' UTR of bcl-2 mRNA. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 382:583-587(2009).
- Huang, S; et al. Perinucleolar structures. JOURNAL OF STRUCTURAL BIOLOGY 129:233-240(2000).
- Yoneyama, K; Kojima, S; et al. Proteomic Identification of Autoantibodies in Sera from Patients with Ovarian Cancer as Possible Diagnostic Biomarkers. ANTICANCER RESEARCH 35:881-889(2015).
