HMGA1
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Official Full Name
high mobility group AT-hook 1 -
Synonyms
HMGA1;high mobility group AT-hook 1;high mobility group (nonhistone chromosomal) protein isoforms I and Y , HMGIY;high mobility group protein HMG-I/HMG-Y;HMG-I(Y);high mobility group protein R;high mobility group protein A1;nonhistone chromosomal h
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
HMGA1 involved in several pathways and played different roles in them. We selected most pathways HMGA1 participated on our site, such as 2-LTR circle formation,APOBEC3G mediated resistance to HIV-1 infection,Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| 2-LTR circle formation | gag,PSIP1,BANF1 |
| DNA Damage/Telomere Stress Induced Senescence | POT1A,UBN1,HMGA1-RS1,HIST1H1E,RAD50,POT1,HIST1H1A,CABIN1,TERF1,HIST1H1D |
| Adipogenesis | MEF2AA,E2F1,AHR,BMP1,EBF1,BSCL2,CREB1,NR1H3,STIL,CEBPB |
| Cellular Senescence | UBN1,SCMH1,EED,MOV10,AGO1,IGFBP7,HIST1H1C,HIST4H4,ERF,HIST1H1A |
| Cellular responses to stress | EEF1A1,DNAJB6,TERF2,AMBRA1B,RB1CC1,HIRA,TXN2,ASF1A,MAPKAPK2B,ATG4A |
| Autointegration results in viral DNA circles | BANF1,PSIP1,gag |
| Disease | TCEB3,TNKS,RCC1,TNKS2,BANF1,NUP35,OS9,gag,CCDC59,CTBP1 |
| APOBEC3G mediated resistance to HIV-1 infection | gag,PSIP1,BANF1,PPIA,APOBEC3G |
Protein Function
HMGA1 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity,AT DNA binding,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGA1 itself. We selected most functions HMGA1 had, and list some proteins which have the same functions with HMGA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | ZBTB49,ARHGEF2,PPP1R13BA,HDAC1,PAX6,NFYC,GATA3,INSIG2,CDKN2A,UBE2I |
| retinoic acid receptor binding | PRAMEF6,AASS,SNW1,PRAMEF2,MED25,MED1,HMGA1-RS1,ASXL1,ACTN4,PRAMEF1 |
| DNA-(apurinic or apyrimidinic site) lyase activity | NTHL1,ALKBH1,NEIL3,HMGA2,HMGA1-RS1,APEX2,APEX1,HMGA1A,RPS3,NEIL2 |
| DNA binding | TAF6L,IRX5A,RXRAA,ERCC3,CHD4,CEBPA,HOXC12A,GCM1,ZNF280D,HSF5 |
| ligand-dependent nuclear receptor transcription coactivator activity | PUS1,FGF2,MED17,SRA1,ZCCHC12,SFR1,USP22,PPARGC1A,CALCOCO1,PRKCB |
| 5-deoxyribose-5-phosphate lyase activity | HMGA1-RS1,XRCC6,HMGA2 |
| peroxisome proliferator activated receptor binding | PPARGC1A,CREBBP,EP300,NFATC4,ASXL2,ASXL1,PRMT2,HMGA1-RS1,MED1,NR0B2 |
| protein binding | EIF4A2,DNAJB11,KCND2,COASY,C17orf82,AKTIP,KIRREL2,VAMP2,ADAMTS10,SIRT2 |
| chromatin binding | FOXO1,ELK1,NR5A1,NCAPD3,FANCM,ZFP932,PPARG,GATA4,PHF21B,CALCOCO1 |
Interacting Protein
HMGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGA1.
SP1;CEBPB;il2ra_human_gene;il2ra_human_+3317/+3478_dna-probe;Stag2;HSP90AB1;HTT;EWSR1;Kifc5b;ssdna_dadts
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References
- Chieffi, P; Chieffi, S; et al. Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overview. JOURNAL OF CELLULAR PHYSIOLOGY 228:1641-1646(2013).
- Chieffi, P; et al. New Prognostic Markers and Potential Therapeutic Targets in Human Testicular Germ Cell Tumors. CURRENT MEDICINAL CHEMISTRY 18:5033-5040(2011).
