HLA-DRB5
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Official Full Name
major histocompatibility complex, class II, DR beta 5 -
Overview
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. -
Synonyms
HLA-DRB5;major histocompatibility complex, class II, DR beta 5;DR beta 5 chain;DR 9;DR beta 5;DR beta-5;DR beta5;DR2 beta 2;DR2-beta-2;DR9;DRB5_HUMAN;Dw2;FLJ76359;HLA class II histocompatibility antigen;HLA class II histocompatibility antigen DR beta 5 chain;HLA class II histocompatibility antigen DRB1-9 beta chain;HLA class II histocompatibility antigen, DR-5 beta chain;HLA DRB;Human leucocyte antigen DRB5;Leukocyte antigen class II;Major histocompatibility complex, class II, DR beta 51;MHC class II antigen DRB1*9;MHC class II antigen DRB5;MHC class II HLA beta chain;MHC HLA-DR-beta cell surface glycoprotein;MHC HLA-DR-beta chain;DR-9;HLA class II histocompatibility antigen, DR beta 5 chain;HLA class II histocompatibility antigen, DRB1-9 beta chain;HLA-DRB
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-DRB5-104H | Recombinant Human HLA-DRB5, His-tagged | HEK293 | Human | His | 30-227 a.a. |
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| HLA-DRB5-5497HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
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| HLA-DRB5-799HCL | Recombinant Human HLA-DRB5 cell lysate | Human | Non |
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| HLA-DRB5-4304H | Recombinant Human HLA-DRB5 protein, His-tagged | E.coli | Human | His | 30-227aa |
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Involved Pathway
HLA-DRB5 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB5 participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Allograft rejection | IL5,GZMB,IFNG,HLA-DQA2,HLA-A,CD86,HLA-DRB3,HLA-DQB1,HLA-F,IL4 |
| Tuberculosis | IFNA13,TLR2,ITGB2,CARD9,NFYC,RFX5,ATP6V0D2,STAT1,IL12A,LBP |
| ne network for IgA production | AICDA,MHC2DAB,TNFSF13,CXCR4A,HLA-DMA,Il2,MADCAM1,CCL27B,ICOSLG,HLA-DMB |
| ne thyroid disease | HLA-DRA,IFNA10,HLA-F,FASLG,HLA-DPB1,IL4,HLA-DMB,IFNA1,IFNA13,HLA-A |
| Graft-versus-host disease | HLA-B,HLA-DRB4,KIR2DL1,IFNG,IL1A,HLA-DMB,HLA-DPA1,TNF,HLA-DQA1,HLA-DQA2 |
| Asthma | PRG2,IL5,CCL11,HLA-DOA,FCER1A,IL13,HLA-DMA,HLA-DQA1,HLA-DOB,CD40LG |
| Phagosome | TAP1,ATP6V1G1,RAB5C,MRC2,RAB5B,H2-AA,C3A.2,ACTB2,CALR,ATP6V1E1B |
| Cell adhesion molecules (CAMs) | NFASC,ALCAMA,CADM1B,H2-AB1,NTNG1,ITGAM,PRPSAP2,L1CAM,HLA-DPA1,PTPRFB |
| Systemic lupus erythematosus | ACTN2,HIST1H2AL,HIST1H4N,HIST2H4A,HIST1H3H,HIST1H2BA,FCGR2A,C8G,HIST1H4G,SNRPD3 |
Protein Function
HLA-DRB5 has several biochemical functions, for example, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB5 itself. We selected most functions HLA-DRB5 had, and list some proteins which have the same functions with HLA-DRB5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | AZGP1,H2-Q10,TUBB3,CLEC4M,HLA-DRA,DHCR24,BF2,HLA-DRB3,MHC1ZE,MHC1UHA |
Interacting Protein
HLA-DRB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB5.
yscP;tolC;mglA3;q81sn0_bacan;q81t03_bacan;q8clt0_yerpe
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References
- Yucesoy, B; Talzhanov, Y; et al. Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations. VACCINE 31:5381-5391(2013).
- Louthrenoo, W; Kasitanon, N; et al. Association of HLA-DRB1*15:02 and DRB5*01:02 allele with the susceptibility to systemic sclerosis in Thai patients. RHEUMATOLOGY INTERNATIONAL 33:2069-2077(2013).
