HLA-DQA1

  • Official Full Name

    major histocompatibility complex, class II, DQ alpha 1

  • Overview

    HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

  • Synonyms

    CD;GSE;DQ-A1;CELIAC1;HLA-DQA;FLJ27088;FLJ27328;MGC149527;HLA-DQA1;HLA class II histocompatibility antigen, DQ alpha 1 chain;HLA-DCA;DC-alpha;DC-1 alpha chain;MHC HLA-DQ alpha;MHC class II DQA1;MHC class II antigen;leucocyte antigen DQA1;MHC class II HLA-DQ-alpha-1;leukocyte antigen alpha chain;MHC class II surface glycoprotein;MHC class II HLA-D alpha glycoprotein;HLA class II histocompatibility antigen, DQ(W3) alpha chain

Recombinant Proteins

  • Human
  • Rhesus macaque
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • HEK293T
  • Mammalian cells
  • His
  • GST
  • Non
  • His&Fc&Avi
  • Myc&DDK
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-DQA1-13815H Recombinant Human HLA-DQA1 protein, His-tagged E.coli Human His 24-220 aa
HLA-DQA1-13819H Recombinant Human HLA-DQA1, GST-tagged E.coli Human GST 24-220a.a.
HLA-DQA1-2102R Recombinant Rhesus monkey HLA-DQA1 Protein, His-tagged Mammalian Cell Rhesus macaque His
HLA-DQA1-29328TH Recombinant Human HLA-DQA1 Wheat Germ Human Non 87 amino acids
HLA-DQA1-4844H Recombinant Human HLA-DQA1 Protein, GST-tagged Wheat Germ Human GST 24-110 a.a.
HLA-DQA1-5507HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-DQA1-1075H Recombinant Human HLA-DQA1 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
HLA-DQA1-1075H-B Recombinant Human HLA-DQA1 Protein Pre-coupled Magnetic Beads HEK293 Human
HLA-DQA1-1923R Recombinant Rhesus Macaque HLA-DQA1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
HLA-DQA1-1923R-B Recombinant Rhesus Macaque HLA-DQA1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
HLA-DQA1-5284H Recombinant Human HLA-DQA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
HLA-DQA1-5291H Recombinant Human HLA-DQA1 protein, His-tagged E.coli Human His 24-213aa
HLA-DQA1-973HFL Recombinant Full Length Human HLA-DQA1 Protein, C-Flag-tagged Mammalian cells Human Flag Full L.

    Involved Pathway

    HLA-DQA1 involved in several pathways and played different roles in them. We selected most pathways HLA-DQA1 participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Herpes simplex infection TYK2,IFIT1,RELA,OAS2,EEF1DA,HLA-DRB3,CLOCKB,PER2,MAP3K7,FASLG
    Leishmaniasis NFKBIB,NOS2,MAPK11,NFKB1,PTGS2,ITGAM,STAT1,TNF,IL12A,FCGR3B
    Antigen processing and presentation HLA-DRB3,CD8B,PDIA3,CALR,HLA-DQB1,NFYC,HSPA1L,KLRC2,LGMN,KLRC4
    Staphylococcus aureus infection CFB,FCGR2B,HLA-DMA,cgr2b,FCGR2A,FCGR3A,FGG,FCGR2C,HLA-DQA2,FCGR4
    Asthma TNF,H2-AA,IL3,EPX,MS4A2,HLA-DOB,H2-AB1,HLA-DMB,IL9,CCL11
    Systemic lupus erythematosus HIST1H4M,HIST1H2BB,CD28,C4A,FCGR3B,C5,C1QC,H3F3C,H2BFWT,HIST1H2BH
    Intestinal i IL-15RA,HLA-DQA2,CCL25B,ICOS,HLA-DQB1,ITGA4,H2-AA,HLA-DPB1,CD86,BLB2
    ne thyroid disease H2-AA,IFNA10,HLA-DQA2,HLA-G,IFNA13,HLA-DMB,HLA-DRB5,IFNA6,IFNA5,H2-AB1
    Rheumatoid arthritis HLA-DMB,ATP6V0A2,TEK,TLR4,IL17A,IFNG,H2-AB1,MMP1,HLA-DOB,ATP6V0A1

    Protein Function

    HLA-DQA1 has several biochemical functions, for example, MHC class II receptor activity,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQA1 itself. We selected most functions HLA-DQA1 had, and list some proteins which have the same functions with HLA-DQA1. You can find most of the proteins on our site.

    Function Related Protein
    peptide antigen binding MHC1UBA,MR1,MHC1UHA,H2-AB1,MHC1ZBA,MHC1UDA,HLA-G,TRGV3,MAML1,TAP1
    MHC class II receptor activity HLA-DPA1,KRT17,HLA-DRB3,HLA-DQA2,HLA-DRA,HLA-DOA,HLA-DRB1,HLA-DQB2,HLA-DOB,HLA-DRB4

    Interacting Protein

    HLA-DQA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQA1.

    HLA-DQB1;CD74;HCRT;CDK7;APLP1;TLE1;UNC119;q5ngv3_fratt;RIF1;SH3GL2;IKBKG

    Resources

    Gene Families

    What is immunoglobulin superfamily (IgSF)

    References

    • Akoglu, G; Metin, A; et al. Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family. INTERNATIONAL JOURNAL OF DERMATOLOGY 54:174-178(2015).
    • Lemin, AJ; Johnson, J; et al. A group-specific sequence-based typing approach for HLA-DQA1. INTERNATIONAL JOURNAL OF IMMUNOGENETICS 42:15-18(2015).

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