HLA-B

  • Official Full Name

    major histocompatibility complex, class I, B

  • Overview

    HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

  • Synonyms

    HLA-B;major histocompatibility complex, class I, B;ankylosing spondylitis , AS;lymphocyte antigen;MHC class I antigen SHCHA;MHC Class I HLA heavy chain;MHC class I antigen GN00104;leukocyte antigen class I-B;MHC HLA-B cell surface glycoprotein;MH

Recombinant Proteins

  • Human
  • E.coli
  • Wheat Germ
  • HEK293
  • Mammalian Cells
  • In Vitro Cell Free System
  • His&T7
  • GST
  • Non
  • Avi&His&Fc
  • Myc&DDK
  • Flag
  • His
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-B-392H Recombinant Human HLA-B protein, His/T7-tagged E.coli Human His&T7 26-309 a.a.
HLA-B-4833H Recombinant Human HLA-B Protein, GST-tagged Wheat Germ Human GST 1-362 a.a.
HLA-B-5495HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-B-1074H Recombinant Human HLA-B Protein, His (Fc)-Avi-tagged HEK293 Human Avi&His&Fc
HLA-B-1074H-B Recombinant Human HLA-B Protein Pre-coupled Magnetic Beads HEK293 Human
HLA-B-1894H Recombinant Human HLA-B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
HLA-B-242HFL Recombinant Full Length Human HLA-B Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
HLA-B-245H Recombinant Human HLA-B Protein, His-tagged E.coli Human His Ser26~Val309
HLA-B-354H Recombinant Human HLA-B Protein, Flag-tagged HEK293 Human Flag
HLA-B-3559HF Recombinant Full Length Human HLA-B Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 362 amino acids
HLA-B-424H Recombinant Human HLA-B protein, His-tagged E.coli Human His 25-309aa
HLA-B-5293H Recombinant Human HLA-B protein, His-tagged E.coli Human His 25-308aa
HLA-B-8392H Recombinant Human HLA-B protein, His-tagged HEK293 Human His

    Involved Pathway

    HLA-B involved in several pathways and played different roles in them. We selected most pathways HLA-B participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Autoi HLA-DPB1,Fasl,GZMB,CD28,HLA-DMB,HLA-DPA1,H2-AA,IFNA6,HLA-DRB3,HLA-A
    Epstein-Barr virus infection POLR3GL,IRAK1,PIK3CG,IKBKG,PSMD12,HLA-F,EIF2AK1,CD58,FCER2,PIK3CA
    Graft-versus-host disease HLA-DRB1,HLA-DMB,HLA-F,KLRC1,IL1A,H2-AB1,HLA-DOA,HLA-DQA1,FASLG,HLA-DMA
    ne thyroid disease TPO,HLA-C,FASLG,PRF1,IL4,IFNA1,HLA-DRB1,IFNA14,CD40,IFNA8
    Endocytosis GRK1,ARPC5A,SPG21,EPS15L1,ARFGAP1,EPN2,WIPF1A,CHMP6,VPS35,PIP5K1BB
    Herpes simplex infection PTPN11,RELA,SRSF6A,IFN-a,PPP1CAA,OAS1A,MHC2DAB,PKZ,HLA-DOB,C3A.3
    Natural killer cell mediated cytotoxicity MAP2K1,SYK,VAV1,KLRC2,LCK,PIK3CG,HLA-A,IFNA13,KIR3DL2,KLRK1
    Allograft rejection H2-Q10,IFNG,HLA-DRB5,HLA-C,HLA-F,Fasl,H2-AA,HLA-DQA1,HLA-DMB,HLA-DOA
    HTLV-I infection ICAM1,MRAS,HLA-DPB1,PIK3CG,PIK3R3,TNFRSF1A,LTA,ZFP36,DLG1,TBPL1

    Protein Function

    HLA-B has several biochemical functions, for example, TAP binding,NOT TAP binding,chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-B itself. We selected most functions HLA-B had, and list some proteins which have the same functions with HLA-B. You can find most of the proteins on our site.

    Function Related Protein
    chaperone binding INS1,Alb,GRPEL1,CDC37,BAG5,DNAJC10,BIRC5,DNAJB1,HSPA5,CP
    peptide antigen binding TUBB3,HLA-E,MAML1,MHC1ZKA,HLA-DPB1,HLA-DQA1,H2-AA,HLA-DRB4,HLA-DRB3,MHC1UXA2
    receptor binding SERPINE1,RARA,ANGPTL1,WNT7AA,WNT7A,CDH5,WNT4A,NPPB,ECH1,LRRC4B
    TAP binding H2-Q10,HLA-C,HLA-A

    Interacting Protein

    HLA-B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-B here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-B.

    HLA-C;STAT1;ltp_ebvg;ARHGEF4;GABARAP

    Resources

    Gene Families

    What is immunoglobulin superfamily (IgSF)

    References

    • Bossini-Castillo, L; de Kovel, C; et al. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
    • Bet, A; Maze, EA; et al. The HIV-1 Antisense Protein (ASP) induces CD8 T cell responses during chronic infection. RETROVIROLOGY 12:-(2015).

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