HIST4H4

  • Official Full Name

    histone cluster 4, H4

  • Overview

    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008]

  • Synonyms

    HIST4H4;histone cluster 4, H4;H4/p;histone H4;histone 4, H4

Recombinant Proteins

  • Human
  • Mouse
  • Wheat Germ
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • His
  • DDK
  • Myc
  • GST
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
HIST4H4-29325TH Recombinant Human HisT4H4, His-tagged Wheat Germ Human His 103 amino acids
Hist4h4-372M Recombinant Mouse Hist4h4 Protein, His-tagged E.coli Mouse His Ser2~Gly103
HIST4H4-401H Recombinant Human HIST4H4 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
HIST4H4-4819H Recombinant Human HIST4H4 Protein, GST-tagged Wheat Germ Human GST
HIST4H4-490H Recombinant Human HIST4H4 protein E.coli Human Non
HIST4H4-5510HCL Recombinant Human HIST4H4 293 Cell Lysate HEK293 Human Non
HIST4H4-229HF Recombinant Full Length Human HisT4H4 Protein, His-tagged In Vitro Cell Free System Human His Full L. 103 amino acids
HIST4H4-3607HF Recombinant Full Length Human HIST4H4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 103 amino acids

    Involved Pathway

    HIST4H4 involved in several pathways and played different roles in them. We selected most pathways HIST4H4 participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3,Alcoholism,Amyloid formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST4H4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular responses to stress EED,TXN,AGO1,ACD,ST13,KDM6B,PTGES3,PHC3,SUZ12B,AGO3
    Alcoholism GNAS,CREB3L1,HDAC7,H2AFB2,GNG10,BRAF,HIST2H2AC,ADORA2A,HIST1H2AC,HIST1H2BO
    Cell Cycle, Mitotic ENSAA,LIN54,MAPRE1B,CLASP1A,CDKN2D,SSNA1,NDEL1B,ARPP19,RANGAP1B,DPF1
    Amyloid formation MFGE8,HIST2H3C,CST3,NAT8B,CEACAM21,APCS,SEMG1,SAA1,RHBDL1,TGFBI
    Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 HIST2H3C,HIST3H2BB,KDM1A,KDM4C,NCOA2
    Cellular Senescence MAPKAPK2B,TERF2IP,SCMH1,ASF1A,CDK6,BMI1B,CBX6,CBX4,CDKN2C,HIST1H1C
    Cell cycle CSNK2A2,CEP76,TGFB3,SMC2,ZBTB17,CSNK1E,H3F3D,CDKN1C,MCM6,YWHABA
    Cell Cycle Checkpoints DBF4,RAD1,CHEK1,RAD9,UIMC1,RAD17,UBE2V2,RNF168,CDKN1B,CLSPN

    Protein Function

    HIST4H4 has several biochemical functions, for example, DNA binding,histone binding,histone demethylase activity (H4-K20 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by HIST4H4 itself. We selected most functions HIST4H4 had, and list some proteins which have the same functions with HIST4H4. You can find most of the proteins on our site.

    Function Related Protein
    histone demethylase activity (H4-K20 specific) HIST1H4A,HIST2H4A,HIST1H4B,HIST1H4H,HIST1H4E,HIST1H4K,HIST1H4F,JHDM1D,HIST1H4J,HIST1H4L
    protein heterodimerization activity BNIP3,IRAK1,WHRN,PDGFB,HER1,HIST1H2B8,NFKB1,FZD1,BMP7A,SOX15
    DNA binding ZNF565,NR1I3,ZNF572,TRIM33,FOXB1A,HIST1H2BJ,SOX12,NR2F5,ZNF157,PLAGL1
    histone binding TONSL,LEF1,HIST1H4F,ATAD2,HAT1,ASF1B,HIST1H4M,WDTC1,PKN1,JAK2
    poly(A) RNA binding GANAB,NUDT21,ALKBH5,ERAL1,NVL,HMGB2,MRPL54,MRPS24,HNRNPF,MRPL27
    protein domain specific binding TFDP1,TACC1,EHD2,TBL1X,TH,LAMP1,NEDD4,HIST2H4A,MECP2,RAPGEF3
    protein binding CFH,CLCNKB,TCF7L2,IRAK2,MFF,TCHP,IL10RB,DAXX,RIC8,NME7

    Interacting Protein

    HIST4H4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST4H4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST4H4.

    KDM4A;TP53BP1;SETD8

    Resources

    Research Area

    H4 Family

    References

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