HIC1
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Official Full Name
hypermethylated in cancer 1 -
Overview
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010] -
Synonyms
HIC1;hypermethylated in cancer 1;hic-1;ZBTB29;ZNF901;hypermethylated in cancer 1 protein;zinc finger and BTB domain-containing protein 29
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- HEK293
- Wheat Germ
- Mammalian Cell
- HEK293T
- Myc&DDK
- Non
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HIC1-245H | Recombinant Human HIC1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| HIC1-29312TH | Recombinant Human HIC1 | Wheat Germ | Human | Non | 79 amino acids |
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| HIC1-463Z | Recombinant Zebrafish HIC1 | Mammalian Cell | Zebrafish | His |
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| HIC1-4744H | Recombinant Human HIC1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HIC1-6789C | Recombinant Chicken HIC1 | Mammalian Cell | Chicken | His |
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| HIC1-7620M | Recombinant Mouse HIC1 Protein | Mammalian Cell | Mouse | His |
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| Hic1-1125M | Recombinant Mouse Hic1 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| HIC1-1409H | Recombinant Human HIC1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| HIC1-4160M | Recombinant Mouse HIC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HIC1-4160M-B | Recombinant Mouse HIC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HIC1 involved in several pathways and played different roles in them. We selected most pathways HIC1 participated on our site, such as Direct p53 effectors,E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Direct p53 effectors | CD82,EDN2,AIFM2,CEBPZ,SCN3B,ZNF385A,NDRG1,EPHA2,PPM1J,DDB2 |
| E2F transcription factor network | CES1,DHFR,HBP1,CES3,E2F6,CDKN2C,YY1,CEBPA,TRIM28,UXT |
Protein Function
HIC1 has several biochemical functions, for example, histone deacetylase binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIC1 itself. We selected most functions HIC1 had, and list some proteins which have the same functions with HIC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ATF6,CITED1,SCML1,TCF12,FOXD1,ZNF812,EVX1,SOX13,STAT1A,NFIL3-3 |
| histone deacetylase binding | RBBP4,HDAC4,SIRT2,FOXP3,MECP2,RELA,CDC20,GMNN,GLI3,XBP1 |
| metal ion binding | NRP2A,ZFPM1,AGFG2,ZC3H8,ZNF592,SP5L,FGG,CAR7,ZNF620,MICAL2B |
| sequence-specific DNA binding | SOX7,RARGB,EVX1,LMX1B,GSX1,BCL11AB,FOXD1,LBX1B,WT1,MSXB |
| protein binding | KLHDC4,ZNF614,KAL1,SUFU,USP44,MYH7B,XBP1,ZNF224,ABCF3,POU4F1 |
Interacting Protein
HIC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIC1.
Ctbp1;CTBP1;TCF7L2
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