HHIP
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Official Full Name
hedgehog interacting protein -
Overview
Hip (HSP70-interacting protein), also known as ST13 (suppression of tumorigenicity protein 13), is one of several co-chaperones that regulate activities of the HSP70 chaperone family (1,2). The homo-oligomeric protein Hip cooperates with HSP70 in protein -
Synonyms
HHIP;hedgehog interacting protein;hedgehog-interacting protein;FLJ20992;HIP;FLJ90230
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- CHO
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
HHIP involved in several pathways and played different roles in them. We selected most pathways HHIP participated on our site, such as cAMP signaling pathway,Hedgehog signaling pathway,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | NCOA4,TPM3,RXRB,HGF,BIRC3,ITGA6,MSH2,F2R,CCDC6,RALGDS |
| Basal cell carcinoma | WNT8B,WNT2,Shh,AXIN2,FZD2,AXIN1,TP53,FZD5,WNT16,FZD8 |
| cAMP signaling pathway | MAPK9,MC2R,CAMK2D,RHOA,AKT1,SLC9A1,FSHR,PDE3B,RAC2,GHSR |
| Hedgehog signaling pathway | FBXW11B,LRP2,WNT5A,SKIA,RAB23,PRKACG,GAS1B,SMO,CSNK1G2B,PRKACBB |
Protein Function
HHIP has several biochemical functions, for example, hedgehog family protein binding,oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HHIP itself. We selected most functions HHIP had, and list some proteins which have the same functions with HHIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| quinone binding | AMOTL1,HHIPL2,NDUFS2,ETFDH,CBR4,AOC2,TP53I3,ABP1,AOC1,VKORC1 |
| zinc ion binding | MORC3A,SUV39H1B,SLC30A8,RXRGA,P2RX1,NEIL1,ZNF257,ZCCHC18,NR5A1B,S100A7 |
| protein binding | PSME3,MLLT6,ZNF187,FGF19,TRIM43,BCL2L2,GPR128,CAMK2G,KIT,CCDC55 |
| oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor | HHIPL2,HHIPL1 |
| hedgehog family protein binding | PTCH1,PTCH2 |
Interacting Protein
HHIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHIP here. Most of them are supplied by our site. Hope this information will be useful for your research of HHIP.
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