HGS
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Official Full Name
hepatocyte growth factor-regulated tyrosine kinase substrate
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Overview
Hepatocyte growth factor-regulated tyrosine kinase substrate . In order to perform this function, HRS is ubiquitinated at its ubiquitin interacting motif (UIM). This allows interaction of HRS with similarly ubiquitinated vesicle-related proteins such as STAM1 and Eps15, as well as ubiquitinated receptors tagged for lysosomal degradation. Complexes of HRS and STAM1 are located in vesicular membranes and regulate the sorting of tagged receptors to the lysosomes. -
Synonyms
HGS; hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Vps27; ZFYVE8; protein pp110; human growth factor-regulated tyrosine kinase substrate; FLJ11421; FLJ39878;
- Recombinant Proteins
- Cell & Tissue Lysates
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- Involved Pathway
- Protein Function
- Interacting Protein
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HGS involved in several pathways and played different roles in them. We selected most pathways HGS participated on our site, such as Endocytosis, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HGS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ERBB3;PSD4;VPS26BL;RAB22A;HLA-F;FGFR3;TSG101A;PSD3;DNM3 |
| Phagosome | TUBB2A;HLA-DMB;MHC1UXA2;NOX3;HLA-C;HLA-DRB1;FCGR3;FCGR2B;THBS4A |
HGS has several biochemical functions, for example, metal ion binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HGS itself. We selected most functions HGS had, and list some proteins which have the same functions with HGS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | BRCC3;LENG9;LIG1;CASZ1;ATP8B3;PHYHD1;PNKD;BMP1B;IRF2BP2A |
| protein binding | BRE;THOC2;DNM1L;KCNQ1;RBM11;VARS;MASP2;CCDC55;DNAJC27 |
| protein domain specific binding | FAF1;HIST1H4H;CACNB2;HNRNPM;VPS4A;GSN;HIST1H4B;PLXND1;TJP2 |
HGS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HGS here. Most of them are supplied by our site. Hope this information will be useful for your research of HGS.
UBC; MIF4GD; LDOC1; DAZAP2
Research Area
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Customer Reviews (3)
Write a reviewMinimal background noise in our assays was indicative of the product's superior quality.
Compatibility with a range of assays expanded our research possibilities significantly.
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Q&As (7)
Ask a questionHGS contributes to the regulation of cell signaling by promoting the downregulation of activated receptors in the endocytic pathway.
Dysregulation or abnormal expression of HGS is associated with conditions such as cancer and neurodegenerative disorders.
HGS participates in the endocytic pathway by facilitating the degradation of receptor tyrosine kinases (RTKs) through the ESCRT complex.
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) functions in cellular processes, primarily playing a role in intracellular trafficking.
HGS is predominantly localized in endosomes and lysosomes, key compartments for the endocytic pathway.
Specific interactions or binding partners of HGS include ESCRT components, influencing its role in receptor downregulation and intracellular trafficking.
There are potential therapeutic implications related to HGS in diseases involving intracellular trafficking and signaling, making it a target for drug development.
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