HES6

  • Official Full Name

    hes family bHLH transcription factor 6

  • Overview

    This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

  • Synonyms

    HES6;hes family bHLH transcription factor 6;HES-6;bHLHb41;bHLHc23;C-HAIRY1;transcription cofactor HES-6;hairy and enhancer of split 6;class B basic helix-loop-helix protein 41

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
HES6-13748H Recombinant Human HES6, His-tagged E.coli Human His 1-224a.a.
HES6-4706H Recombinant Human HES6 Protein, GST-tagged Wheat Germ Human GST
HES6-7590M Recombinant Mouse HES6 Protein Mammalian Cell Mouse His
HES6-9750Z Recombinant Zebrafish HES6 Mammalian Cell Zebrafish His
HES6-5580HCL Recombinant Human HES6 293 Cell Lysate HEK293 Human Non
Hes6-3387M Recombinant Mouse Hes6 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
HES6-3520HF Recombinant Full Length Human HES6 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 224 amino acids
HES6-4135M Recombinant Mouse HES6 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
HES6-4135M-B Recombinant Mouse HES6 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HES6 involved in several pathways and played different roles in them. We selected most pathways HES6 participated on our site, such as Delta-Notch Signaling Pathway,Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with HES6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Delta-Notch Signaling Pathway HIVEP3,ADAM10A,YY1,ASCL1A,HEY1,APPA,CNTN1B,RING1,ZFPM1,JAG2
    Notch-mediated HES/HEY network HEY1,TLE1,MYB,CTBP1,MYOD1,GATA6,GATA1,RCAN1,BGLAP,ASCL1

    Protein Function

    HES6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,protein dimerization activity,transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HES6 itself. We selected most functions HES6 had, and list some proteins which have the same functions with HES6. You can find most of the proteins on our site.

    Function Related Protein
    protein dimerization activity TFE3,EPAS1B,NPAS4A,NPAS2,MYCS,ATOH1,HES2,MSC,LYL1,HPSE
    RNA polymerase II regulatory region sequence-specific DNA binding PRKCBP1L,ZNF79,HMX1,ZBTB4,SNAI1,SP3,PHF21A,POU3F4,RELB,HOXD8
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding CDX2,NR2F6,FEZF2,PURB,HIST2H3A,FOXD3,E2F7,ETV6,NFKB1,ZC3H8
    transcription factor activity, sequence-specific DNA binding TBP,ZFP27,TGIF1,NFIC,ATF7A,TP63,ZNF165,ZNF92,MGAA,ATF6B
    transcription factor binding DRAP1,HES7,MAPK9,TLE1,TBP,BCOR,E2F2,NFKB1,PURA,PARP1
    transcription cofactor activity MSX2,TAF13,MED16,MAX,PRKCBP1L,IRF3,MAP3K7,LDB1B,MED4,MXD1

    Interacting Protein

    HES6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HES6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HES6.

    TWIST1

    Resources

    References

    • Son, YS; Park, JH; et al. Heat shock 70-kDa protein 8 isoform 1 is expressed on the surface of human embryonic stem cells and downregulated upon differentiation. STEM CELLS 23:1502-1513(2005).
    • Schroter, C; Ares, S; et al. Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit. PLOS BIOLOGY 10:-(2012).

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