HCRT
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Official Full Name
hypocretin (orexin) neuropeptide precursor -
Overview
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. -
Synonyms
HCRT;hypocretin (orexin) neuropeptide precursor;orexin;OX;PPOX;Hcrt2;Hypocretin 2;hypocretin;NRCLP1;Orexin precursor;prepro orexin
Recombinant Proteins
- Rhesus macaque
- Mouse
- Rat
- Zebrafish
- Chicken
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- GST&His
- His&SUMO
- Avi&Fc&His
Involved Pathway
HCRT involved in several pathways and played different roles in them. We selected most pathways HCRT participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCRT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | PENK,GPR39,EFCAB7,NEDD8,PCSK6,ARHGAP32,ARHGAP23,OR52B4,NOG,FAM13A |
| GPCR ligand binding | CRHB,HRH3,CCL35.2,SST,RLN3A,SSTR5,EDNRA,APLN,FPR-RS6,CALCRL |
| Peptide ligand-binding receptors | PROK1,CX3CR1,APLNR,EDN3,NTS,PENKA,NMBA,PROK2,SSTR5,PENK |
| Gastrin-CREB signalling pathway via PKC and MAPK | ANXA1B,GRP,EDN2,NPS,PMCH,DGKQ,NMUR1,GPR65,GPR132B,GCGB |
| G alpha (q) signalling events | OPN4,MLN,NMUR1,DGKB,PROKR1,DGKA,EDN1,CASR,TAC2,PROK1 |
| GPCR downstream signaling | TRPC6A,DGKG,ANXA1,PTHLH,UTS2D,TRIO,RLN2,ADCYAP1B,GPRC6A,FFAR3 |
| Orexin and neuropeptides FF and QRFP bind to their respective receptors | QRFPR,NPFF,NPFFR2,QRFP |
| Class A/1 (Rhodopsin-like receptors) | LTB4R,RLN3,CNR1,PENKA,DRD3,NMBA,KEL,CHRM4,CYSLTR1,CCR6 |
Protein Function
HCRT has several biochemical functions, for example, neuropeptide hormone activity,type 1 hypocretin receptor binding,type 2 hypocretin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCRT itself. We selected most functions HCRT had, and list some proteins which have the same functions with HCRT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neuropeptide hormone activity | ADCYAP1,GAL,VIP,POMCA,NTS,CCK,QRFP,CRH,NPY,GRP |
Interacting Protein
HCRT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCRT here. Most of them are supplied by our site. Hope this information will be useful for your research of HCRT.
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References
- Sato, H; Suzuki, Y; et al. HLA Class I Expression and Its Alteration by Preoperative Hyperthermo-Chemoradiotherapy in Patients with Rectal Cancer. PLOS ONE 9:-(2014).
- Chen, XY; Li, R; et al. Identification of differentially expressed genes in hypothalamus of chicken during cold stress. MOLECULAR BIOLOGY REPORTS 41:2243-2248(2014).
